Recent publications published by researchers at the MRC WIMM.
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Tsukada K. et al, (2024), Mol Cell, 84, 640 - 658.e10
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.
Rodriguez-Meira A. et al, (2023), Nat Genet, 55, 1531 - 1541
53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis.
Mirman Z. et al, (2022), Nat Cell Biol, 24, 51 - 61
BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination.
Becker JR. et al, (2021), Nature, 596, 433 - 437
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Hewitt G. et al, (2021), Mol Cell, 81, 767 - 783.e11
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.
Yeow ZY. et al, (2020), Nature, 585, 447 - 452
Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.
Francica P. et al, (2020), Cell Rep, 32
An essential role for the Zn2+ transporter ZIP7 in B cell development.
Anzilotti C. et al, (2019), Nat Immunol, 20, 350 - 361
H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
Nakamura K. et al, (2019), Nat Cell Biol, 21, 311 - 318
H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids
Nakamura K. et al, (2019), NATURE CELL BIOLOGY, 21, 311 - +
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.
Becker JR. et al, (2018), Nat Commun, 9
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Ghezraoui H. et al, (2018), Nature, 560, 122 - 127
Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Botuyan MV. et al, (2018), Nat Struct Mol Biol, 25, 591 - 600