Recent publications published by researchers at the MRC WIMM.
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting
Deobagkar-Lele M. et al, (2024), Science Immunology, 9
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
Lippert AH. et al, (2024), Immunity, 57, 256 - 270.e10
Tissue-resident memory T cells in pancreatic ductal adenocarcinoma co-express PD-1 and TIGIT and functional inhibition is reversible by dual antibody blockade.
Pearce H. et al, (2023), Cancer Immunol Res
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-Like Autoimmunity.
Hodgson R. et al, (2023), J Immunol
NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.
Hodgson R. et al, (2022), Commun Biol, 5
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison.
National SARS-CoV-2 Serology Assay Evaluation Group None., (2020), Lancet Infect Dis, 20, 1390 - 1400
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Peng Y. et al, (2020), Nat Immunol, 21, 1336 - 1345
SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
Lumley SF. et al, (2020), Euro Surveill, 25
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.
Burrows N. et al, (2020), Nat Immunol
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.
Eyre DW. et al, (2020), Elife, 9
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel
Adams E. et al, (2020)
Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.
Peng Y. et al, (2020), bioRxiv
An ontogenetic switch drives the positive and negative selection of B cells.
Xu X. et al, (2020), Proc Natl Acad Sci U S A, 117, 3718 - 3727
Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel.
Adams ER. et al, (2020), Wellcome open research, 5
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.
Abeler-Dörner L. et al, (2020), Nat Immunol, 21, 86 - 100
Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis.
Liu Y-H. et al, (2020), Front Immunol, 11
An essential role for the Zn2+ transporter ZIP7 in B cell development.
Anzilotti C. et al, (2019), Nat Immunol, 20, 350 - 361
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Ghezraoui H. et al, (2018), Nature, 560, 122 - 127
Partial retinal photoreceptor loss in a transgenic mouse model associated with reduced levels of interphotoreceptor retinol binding protein (IRBP, RBP3).
Liu Y-H. et al, (2018), Exp Eye Res, 172, 54 - 65