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Publications

Recent publications published by researchers at the MRC WIMM.

XPF-ERCC1: Linchpin of DNA crosslink repair.

McHugh PJ., (2020), PLoS Genet, 16

Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.

Swift LP. et al, (2020), 2119, 79 - 88

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.

Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351

Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.

Dürr E-M. et al, (2018), ChemistrySelect, 3, 12824 - 12829

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP. et al, (2018), Sci Rep, 8

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Ronson GE. et al, (2018), Nat Commun, 9

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R. et al, (2018), J Med Chem, 61, 1255 - 1260

Discovery of prognostic and predictive tissue biomarkers in patients with resectable esophageal cancer

MacGregor TP. et al, (2014), JOURNAL OF CLINICAL ONCOLOGY, 32

Use of DNA repair proteins translated from biomarker screening to predict overall survival in patients with esophageal cancer treated with oxaliplatin chemotherapy

Sharma RA. et al, (2012), JOURNAL OF CLINICAL ONCOLOGY, 30

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Wang AT. et al, (2011), Genes Dev, 25, 1859 - 1870

Mgm101, a mitochondrial genome maintenance factor, also plays a role in the repair of nuclear DNA cross- links

Ward TA. et al, (2007), MUTAGENESIS, 22, 453 - 454

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Hartley JA. et al, (2004), Cancer Res, 64, 6693 - 6699

Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin.

De Silva IU. et al, (2002), Nucleic Acids Res, 30, 3848 - 3856

PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells.

Grimaldi KA. et al, (2002), Mol Biotechnol, 20, 181 - 196

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

McHugh PJ. et al, (2001), Lancet Oncol, 2, 483 - 490

Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses.

McGurk CJ. et al, (2001), Methods Enzymol, 340, 358 - 376

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