Recent publications published by researchers at the MRC WIMM.
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Journal article
Mengoli V. et al, (2022), EMBO J
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock HT. et al, (2022), Nucleic Acids Research
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Journal article
Baddock HT. et al, (2021), Nucleic acids research
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Journal article
Yosaatmadja Y. et al, (2021), Nucleic Acids Res
Neuronal enhancers are hotspots for DNA single-strand break repair.
Journal article
Wu W. et al, (2021), Nature
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
Journal article
MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Journal article
Yosaatmadja Y. et al, (2021)
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
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van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
BADDOCK HT. et al, (2020), bioRxiv
Genetic and functional insights into CDA-I prevalence and pathogenesis.
Journal article
Olijnik A-A. et al, (2020), J Med Genet
Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.
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Swift LP. et al, (2020), 2119, 79 - 88
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
Journal article
Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Journal article
Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105
Microhomologies are prevalent at Cas9-induced larger deletions.
Journal article
Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417
Antiviral activity of bone morphogenetic proteins and activins.
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Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351
Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.
Journal article
Dürr E-M. et al, (2018), ChemistrySelect, 3, 12824 - 12829