Recent publications published by researchers at the MRC WIMM.
SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Swift LP. et al, (2024), Nat Commun, 15
SNM1A is crucial for efficient repair of complex DNA breaks in human cells
MCHUGH P., (2024), Nature Communications
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target
Bielinski M. et al, (2024), Chemical Science
N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells
Emms VL. et al, (2023), Chemical Science
N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells
Emms VL. et al, (2023), CHEMICAL SCIENCE, 14, 12498 - 12505
SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells
McHugh P. et al, (2023)
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Mengoli V. et al, (2022), EMBO J
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Baddock HT. et al, (2022), Nucleic Acids Research
Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases.
Turchi JJ. et al, (2022), Front Oncol, 12
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Baddock HT. et al, (2021), Nucleic acids research
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Yosaatmadja Y. et al, (2021), Nucleic Acids Res
Genetic and functional insights into CDA-I prevalence and pathogenesis.
Olijnik A-A. et al, (2021), J Med Genet, 58, 185 - 195
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Yosaatmadja Y. et al, (2021)
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298