Recent publications published by researchers at the MRC WIMM.
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Journal article
Yosaatmadja Y. et al, (2021)
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Journal article
van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
Genetic and functional insights into CDA-I prevalence and pathogenesis.
Journal article
Olijnik A-A. et al, (2020), J Med Genet
Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.
Chapter
Swift LP. et al, (2020), 2119, 79 - 88
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
Journal article
Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Journal article
Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105
Microhomologies are prevalent at Cas9-induced larger deletions.
Journal article
Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417
Antiviral activity of bone morphogenetic proteins and activins.
Journal article
Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351
Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.
Journal article
Dürr E-M. et al, (2018), ChemistrySelect, 3, 12824 - 12829
Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.
Journal article
Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428
Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.
Journal article
MacGregor TP. et al, (2018), Sci Rep, 8
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.
Journal article
Ronson GE. et al, (2018), Nat Commun, 9
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.
Journal article
Cain R. et al, (2018), J Med Chem, 61, 1255 - 1260
Discovery of prognostic and predictive tissue biomarkers in patients with resectable esophageal cancer
Journal article
MacGregor TP. et al, (2014), JOURNAL OF CLINICAL ONCOLOGY, 32
Use of DNA repair proteins translated from biomarker screening to predict overall survival in patients with esophageal cancer treated with oxaliplatin chemotherapy
Conference paper
Sharma RA. et al, (2012), JOURNAL OF CLINICAL ONCOLOGY, 30
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.
Journal article
Wang AT. et al, (2011), Genes Dev, 25, 1859 - 1870