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Recent publications published by researchers at the MRC WIMM.

XPF-ERCC1: Linchpin of DNA crosslink repair.

Journal article

McHugh PJ., (2020), PLoS Genet, 16

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.

Journal article

Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Journal article

Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105

Microhomologies are prevalent at Cas9-induced larger deletions.

Journal article

Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417

Antiviral activity of bone morphogenetic proteins and activins.

Journal article

Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351

Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.

Journal article

Dürr E-M. et al, (2018), ChemistrySelect, 3, 12824 - 12829

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Journal article

Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Journal article

Cain R. et al, (2018), J Med Chem, 61, 1255 - 1260

Discovery of prognostic and predictive tissue biomarkers in patients with resectable esophageal cancer

Journal article

MacGregor TP. et al, (2014), JOURNAL OF CLINICAL ONCOLOGY, 32

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Journal article

Wang AT. et al, (2011), Genes Dev, 25, 1859 - 1870

PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells.

Journal article

Grimaldi KA. et al, (2002), Mol Biotechnol, 20, 181 - 196

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.

Journal article

McHugh PJ. et al, (2001), Lancet Oncol, 2, 483 - 490

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