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Publications

Recent publications published by researchers at the MRC WIMM.

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

The SNM1A DNA repair nuclease.

Baddock HT. et al, (2020), DNA Repair (Amst), 95

Genetic and functional insights into CDA-I prevalence and pathogenesis.

Olijnik A-A. et al, (2020), J Med Genet

XPF-ERCC1: Linchpin of DNA crosslink repair.

McHugh PJ., (2020), PLoS Genet, 16

Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.

Swift LP. et al, (2020), 2119, 79 - 88

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.

Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351

Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.

Dürr E-M. et al, (2018), ChemistrySelect, 3, 12824 - 12829

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP. et al, (2018), Sci Rep, 8

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Ronson GE. et al, (2018), Nat Commun, 9

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R. et al, (2018), J Med Chem, 61, 1255 - 1260

Discovery of prognostic and predictive tissue biomarkers in patients with resectable esophageal cancer

MacGregor TP. et al, (2014), JOURNAL OF CLINICAL ONCOLOGY, 32

Use of DNA repair proteins translated from biomarker screening to predict overall survival in patients with esophageal cancer treated with oxaliplatin chemotherapy

Sharma RA. et al, (2012), JOURNAL OF CLINICAL ONCOLOGY, 30

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Wang AT. et al, (2011), Genes Dev, 25, 1859 - 1870

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