Recent publications published by researchers at the MRC WIMM.
N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells
Journal article
Emms VL. et al, (2023), Chemical Science
N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells
Journal article
Emms VL. et al, (2023), CHEMICAL SCIENCE, 14, 12498 - 12505
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Journal article
Mengoli V. et al, (2022), EMBO J
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock HT. et al, (2022), Nucleic Acids Research
Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases.
Journal article
Turchi JJ. et al, (2022), Front Oncol, 12
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Journal article
Baddock HT. et al, (2021), Nucleic acids research
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Journal article
Yosaatmadja Y. et al, (2021), Nucleic Acids Res
Neuronal enhancers are hotspots for DNA single-strand break repair.
Journal article
Wu W. et al, (2021), Nature
Genetic and functional insights into CDA-I prevalence and pathogenesis.
Journal article
Olijnik A-A. et al, (2021), J Med Genet, 58, 185 - 195
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
Journal article
MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Journal article
Yosaatmadja Y. et al, (2021)
Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
Journal article
van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
Baddock H. et al, (2020)
Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Journal article
BADDOCK HT. et al, (2020), bioRxiv
Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.
Chapter
Swift LP. et al, (2020), 2119, 79 - 88
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
Journal article
Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Journal article
Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105