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Publications

Recent publications published by researchers at the MRC WIMM.

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.

Baddock HT. et al, (2021), Nucleic acids research

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Yosaatmadja Y. et al, (2021), Nucleic Acids Res

Neuronal enhancers are hotspots for DNA single-strand break repair.

Wu W. et al, (2021), Nature

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core

MCHUGH P. and PTCHELKINE D., (2021), Nucleic Acids Research Cancer

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Yosaatmadja Y. et al, (2021)

Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

van Wietmarschen N. et al, (2020), Nature, 586, 292 - 298

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock H. et al, (2020)

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

BADDOCK HT. et al, (2020), bioRxiv

The SNM1A DNA repair nuclease.

Baddock HT. et al, (2020), DNA Repair (Amst), 95

Genetic and functional insights into CDA-I prevalence and pathogenesis.

Olijnik A-A. et al, (2020), J Med Genet

XPF-ERCC1: Linchpin of DNA crosslink repair.

McHugh PJ., (2020), PLoS Genet, 16

Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.

Swift LP. et al, (2020), 2119, 79 - 88

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.

Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA. et al, (2019), Nat Microbiol, 4, 339 - 351

Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.

Dürr E-M. et al, (2018), ChemistrySelect, 3, 12824 - 12829

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R. et al, (2018), Cell Rep, 23, 3419 - 3428

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.

MacGregor TP. et al, (2018), Sci Rep, 8

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