Recent publications published by researchers at the MRC WIMM.
Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodies.
Sprumont A. et al, (2023), Cell, 186, 5486 - 5499.e13
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center.
Grootveld AK. et al, (2023), Cell, 186, 1144 - 1161.e18
Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.
MacLean AJ. et al, (2022), Immunity, 55, 718 - 733.e8
Competition for refueling rather than cyclic reentry initiation evident in germinal centers.
Long Z. et al, (2022), Sci Immunol, 7
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
Frost JN. et al, (2021), Med, 2, 164 - 179.e12
Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging.
Stewart I. et al, (2018), Immunity, 49, 477 - 489.e7
Expression of the Plasma Cell Transcriptional Regulator Blimp-1 by Dark Zone Germinal Center B Cells During Periods of Proliferation.
Radtke D. and Bannard O., (2018), Front Immunol, 9
Germinal centers: programmed for affinity maturation and antibody diversification.
Bannard O. and Cyster JG., (2017), Curr Opin Immunol, 45, 21 - 30
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.
Bannard O. et al, (2016), J Exp Med, 213, 993 - 1009
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells.
Rodda LB. et al, (2015), J Immunol, 195, 4781 - 4791
Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.
Dos Santos LI. et al, (2015), Cancer Immunol Immunother, 64, 311 - 323
Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness.
Wang X. et al, (2014), J Immunol, 192, 4601 - 4609
Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection.
Bannard O. et al, (2013), Immunity, 39, 912 - 924
The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
Baumjohann D. et al, (2013), Nat Immunol, 14, 840 - 848
CXCR4 promotes B cell egress from Peyer's patches.
Schmidt TH. et al, (2013), J Exp Med, 210, 1099 - 1107
MIR-17 ∼ 92 promotes T follicular helper cell differentiation and represses subset-inappropriate gene expression
Baumjohann D. et al, (2013), CYTOKINE, 63, 246 - 247
Immunology. When less signaling is more.
Bannard OM. and Cyster JG., (2012), Science, 336, 1120 - 1121
Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.
Mackay LK. et al, (2012), J Immunol, 188, 2173 - 2178
Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection.
Bannard O. et al, (2010), J Immunol, 185, 7141 - 7145