Recent publications published by researchers at the MRC WIMM.
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Muskens IS. et al, (2021), Nat Commun, 12
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
Louka E. et al, (2021), J Exp Med, 218
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Godfrey L. et al, (2021), Leukemia, 35, 90 - 106
Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.
Cruz Hernandez D. et al, (2020), Blood, 136, 1460 - 1465
Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome
O'Byrne SI. et al, (2019), Blood, 134, 1206 - 1206
Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.
O'Byrne S. et al, (2019), Blood, 134, 1059 - 1071
Most haematological abnormalities in neonates with Down syndrome are transient but dysplastic myelopoiesis persists throughout early childhood
Hanssen L. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 106 - 106
Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia
Louka E. et al, (2017), BLOOD, 130
RE-ORDERING THE B CELL DEVELOPMENT HIERARCHY IN HUMAN FETAL BONE MARROW: CHARACTERISATION OF A NOVEL HUMAN FETAL B PROGENITOR
O'Byrne S. et al, (2017), HAEMATOLOGICA, 102, 80 - 80
GENOME WIDE DYSREGULATION OF GENE EXPRESSION BY TRISOMY 21 IN FETAL LIVER HAEMATOPOIETIC STEM AND PROGENITOR CELLS
Roy A. et al, (2016), HAEMATOLOGICA, 101, 120 - 120
Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.
Goodings C. et al, (2015), Stem Cells, 33, 2628 - 2641
Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias
Goodings C. et al, (2015), Leukemia Research, 39, 100 - 109
Clinical and Hematologic Impact of Fetal and Perinatal Variables on Mutant GATA1 Clone Size in Neonates with Down Syndrome
Bhatnagar N. et al, (2014), BLOOD, 124
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4
Cleveland SM. et al, (2014), Experimental Hematology, 42, 581 - 593.e5
Hhex Is a Critical Gene In The Development Of Normal and Malignant Lymphoid Cells
Goodings C. et al, (2013), Blood, 122, 3788 - 3788
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma
Elliott NE. et al, (2011), Blood, 118, 3911 - 3921