Recent publications published by researchers at the MRC WIMM.
In silico engineering a CD80 variant with increased affinity to CTLA-4 and decreased affinity to CD28 for optimized cancer immunotherapy.
Journal article
Hajihassan Z. et al, (2023), J Immunol Methods, 513
Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma.
Journal article
Gooding S. et al, (2022), Blood, 140, 1816 - 1821
Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.
Journal article
Ansari-Pour N. et al, (2022), Blood
Clonal diversification and histogenesis of malignant germ cell tumours.
Journal article
Oliver TRW. et al, (2022), Nat Commun, 13
Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma.
Journal article
Sudha P. et al, (2022), Clin Cancer Res, 28, 2854 - 2864
Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes.
Journal article
Ansari-Pour N. et al, (2021), Nat Commun, 12
A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma
Conference paper
Sudha P. et al, (2021), BLOOD, 138
Loss of COP9 Signalosome Gene-Containing 2q Region Is Associated with Lenalidomide and Pomalidomide Resistance in Myeloma Patients
Conference paper
Gooding S. et al, (2021), BLOOD, 138
Single-cell whole-exome DNA sequencing traces clonal trajectory in paired evolution of MGUS to multiple myeloma
Conference paper
Ansari-Pour N. et al, (2021), CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 21, S72 - S72
Genomic and evolutionary classification of lung cancer in never smokers
Journal article
Zhang T. et al, (2021), Nature Genetics, 53, 1348 - 1359
Association of MSY haplotype background with nonobstructive azoospermia is AZF-dependent: A case-control study.
Journal article
Seyedin A. et al, (2021), Andrologia, 53
Re-evaluating experimental validation in the Big Data Era: a conceptual argument.
Journal article
Jafari M. et al, (2021), Genome Biol, 22
Group-based pharmacogenetic prediction: is it feasible and do current NHS England ethnic classifications provide appropriate data?
Journal article
Ingram CJE. et al, (2021), Pharmacogenomics J, 21, 47 - 59
Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.
Journal article
Gooding S. et al, (2021), Blood, 137, 232 - 237
Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases.
Journal article
Rabbie R. et al, (2020), Nat Commun, 11
Multiple Cereblon genetic changes associate with acquired resistance to Lenalidomide or Pomalidomide in Multiple Myeloma.
Journal article
Gooding S. et al, (2020), Blood
Can We Assume the Gene Expression Profile as a Proxy for Signaling Network Activity?
Journal article
Piran M. et al, (2020), Biomolecules, 10
A novel gene-wide haplotype at the macrophage migration inhibitory factor (MIF) locus is associated with endometrioma.
Journal article
Chekini Z. et al, (2020), Eur J Obstet Gynecol Reprod Biol, 247, 6 - 9
Genetic and Transcript Changesin Cereblon in IMiD-Treated Myeloma Patients
Conference paper
Gooding S. et al, (2019), BLOOD, 134
Large-Scale Analysis of Relapsed/Refractory Multiple Myeloma Genome Reveals Increased Prevalence of High-Risk Molecular Features and Oncogenic Drivers
Conference paper
Towfic F. et al, (2019), BLOOD, 134