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Publications

Recent publications published by researchers at the MRC WIMM.

In silico engineering a CD80 variant with increased affinity to CTLA-4 and decreased affinity to CD28 for optimized cancer immunotherapy.

Hajihassan Z. et al, (2023), J Immunol Methods, 513

Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma.

Gooding S. et al, (2022), Blood, 140, 1816 - 1821

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Ansari-Pour N. et al, (2022), Blood

Clonal diversification and histogenesis of malignant germ cell tumours.

Oliver TRW. et al, (2022), Nat Commun, 13

Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma.

Sudha P. et al, (2022), Clin Cancer Res, 28, 2854 - 2864

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes.

Ansari-Pour N. et al, (2021), Nat Commun, 12

A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma

Sudha P. et al, (2021), BLOOD, 138

Loss of COP9 Signalosome Gene-Containing 2q Region Is Associated with Lenalidomide and Pomalidomide Resistance in Myeloma Patients

Gooding S. et al, (2021), BLOOD, 138

Single-cell whole-exome DNA sequencing traces clonal trajectory in paired evolution of MGUS to multiple myeloma

Ansari-Pour N. et al, (2021), CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 21, S72 - S72

Genomic and evolutionary classification of lung cancer in never smokers

Zhang T. et al, (2021), Nature Genetics, 53, 1348 - 1359

Association of MSY haplotype background with nonobstructive azoospermia is AZF-dependent: A case-control study.

Seyedin A. et al, (2021), Andrologia, 53

Re-evaluating experimental validation in the Big Data Era: a conceptual argument.

Jafari M. et al, (2021), Genome Biol, 22

Group-based pharmacogenetic prediction: is it feasible and do current NHS England ethnic classifications provide appropriate data?

Ingram CJE. et al, (2021), Pharmacogenomics J, 21, 47 - 59

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.

Gooding S. et al, (2021), Blood, 137, 232 - 237

Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases.

Rabbie R. et al, (2020), Nat Commun, 11

Multiple Cereblon genetic changes associate with acquired resistance to Lenalidomide or Pomalidomide in Multiple Myeloma.

Gooding S. et al, (2020), Blood

Can We Assume the Gene Expression Profile as a Proxy for Signaling Network Activity?

Piran M. et al, (2020), Biomolecules, 10

A novel gene-wide haplotype at the macrophage migration inhibitory factor (MIF) locus is associated with endometrioma.

Chekini Z. et al, (2020), Eur J Obstet Gynecol Reprod Biol, 247, 6 - 9

Genetic and Transcript Changesin Cereblon in IMiD-Treated Myeloma Patients

Gooding S. et al, (2019), BLOOD, 134

Large-Scale Analysis of Relapsed/Refractory Multiple Myeloma Genome Reveals Increased Prevalence of High-Risk Molecular Features and Oncogenic Drivers

Towfic F. et al, (2019), BLOOD, 134

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