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Publications

Recent publications published by researchers at the MRC WIMM.

The characteristics of CTCF binding sequences contribute to enhancer blocking activity.

Tsang FH. et al, (2024), Nucleic Acids Res

Super-enhancers include classical enhancers and facilitators to fully activate gene expression.

Blayney JW. et al, (2023), Cell, 186, 5826 - 5839.e18

Understanding fundamental principles of enhancer biology at a model locus: Analysing the structure and function of an enhancer cluster at the α-globin locus.

Kassouf M. et al, (2023), Bioessays, 45

Active regulatory elements recruit cohesin to establish cell-specific chromatin domains

Georgiades E. et al, (2023)

Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during differentiation

Stolper R. et al, (2023)

The characteristics of CTCF binding sequences contribute to enhancer blocking activity

Tsang F. et al, (2023)

Scalable in vitro production of defined mouse erythroblasts.

Francis HS. et al, (2022), PLoS One, 17

Reactivation of a developmentally silenced embryonic globin gene.

King AJ. et al, (2021), Nat Commun, 12

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

Oudelaar AM. et al, (2021), Curr Opin Genet Dev, 67, 18 - 24

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.

Brown JM. et al, (2018), Nat Commun, 9

Between form and function: the complexity of genome folding.

Oudelaar AM. et al, (2017), Hum Mol Genet, 26, R208 - R215

Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

Hanssen LLP. et al, (2017), Nat Cell Biol, 19, 952 - 961

Genetic dissection of the α-globin super-enhancer in vivo.

Hay D. et al, (2016), Nat Genet, 48, 895 - 903

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.

Chagraoui H. et al, (2011), Blood, 118, 723 - 735

Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.

Kassouf MT. et al, (2010), Genome Res, 20, 1064 - 1083

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.

Kassouf MT. et al, (2008), Blood, 112, 1056 - 1067

Characterisation of SCL DNA-binding functions in vivo in haematopoiesis.

Kassouf M. et al, (2005), BLOOD, 106, 493A - 493A

Include forthcoming?