Recent publications published by researchers at the MRC WIMM.
TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.
Journal article
Haase D. et al, (2019), Leukemia, 33, 1747 - 1758
Therapy-Related Myeloid Neoplasms with Balanced Chromosome Rearrangements Frequently Arise from Pre-Existing Clonal Haematopoiesis
Conference paper
Dillon R. et al, (2018), BLOOD, 132
Salvage chemotherapy and donor lymphocyte infusion induces durable remissions in AML relapsing following allogeneic stem cell transplantation
Conference paper
Lubowiecki M. et al, (2018), BONE MARROW TRANSPLANTATION, 53, 184 - 185
Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.
Journal article
Quek L. et al, (2018), Nat Med, 24, 1167 - 1177
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
Journal article
Karamitros D. et al, (2018), Nat Immunol, 19, 85 - 97
A Novel Model of Human Hemopoiesis Based on Single Cell Functional and Transcriptional Analysis of Lympho-Myeloid Progenitors
Conference paper
Stoilova B. et al, (2017), BLOOD, 130
Clonal Heterogeneity in Differentiation Response and Resistance to the IDH2 Inhibitor Enasidenib in Acute Myeloid Leukemia
Conference paper
Quek L. et al, (2017), BLOOD, 130
Outcome of Azacitidine Therapy in Acute Myeloid Leukemia Is not Improved by Concurrent Vorinostat Therapy but Is Predicted by a Diagnostic Molecular Signature.
Journal article
Craddock CF. et al, (2017), Clin Cancer Res, 23, 6430 - 6440
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Journal article
Mettananda S. et al, (2017), Nat Commun, 8
Identifying the optimum source of mesenchymal stem cells for use in knee surgery.
Journal article
Davies BM. et al, (2017), J Orthop Res, 35, 1868 - 1875
SINGLE CELL ASSAYS UNVEIL FUNCTIONAL AND TRANSCRIPTIONAL HETEROGENEITY OF HUMAN HEMOPOIETIC LYMPHO-MYELOID PROGENITORS
Conference paper
Stoilova B. et al, (2017), Experimental Hematology, 53
Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.
Journal article
Amatangelo MD. et al, (2017), Blood, 130, 732 - 741
A NOVEL MODEL OF HUMAN LYMPHO-MYELOID PROGENITOR HIERARCHY BASED ON SINGLE CELL FUNCTIONAL AND TRANSCRIPTIONAL ANALYSIS
Conference paper
Karamitros D. et al, (2017), HAEMATOLOGICA, 102, 20 - 20
MOLECULAR PREDICTORS OF RESPONSE TO AZACITIDINE THERAPY: THE RESULTS OF THE UK TRIALS ACCELERATION PROGRAMME RAVVA STUDY
Conference paper
Craddock C. et al, (2017), HAEMATOLOGICA, 102, 323 - 323
Analysis of arginine metabolism in acute myeloid leukaemia to provide insights into tumour immune escape strategies
Conference paper
Hadjinicolaou AV. et al, (2017), LANCET, 389, 42 - 42
Mutational analysis of disease relapse in patients allografted for acute myeloid leukemia.
Journal article
Quek L. et al, (2016), Blood Adv, 1, 193 - 204
Vorinostat Does Not Improve Outcome in Patients with Acute Myeloid Leukemia and High Risk Myelodysplasia Treated with Azacitidine: Results of the UK Trials Acceleration Programme Ravva Trial
Conference paper
Craddock C. et al, (2016), BLOOD, 128
Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.
Journal article
Quek L. et al, (2016), J Exp Med, 213, 1513 - 1535
NGS IDENTIFIES MUTATIONS PROGNOSTIC OF RELAPSE AFTER ALLO-SCT AND NOVEL CLONE EMERGENCE AT DISEASE RECURRENCE: IMPLICATIONS FOR STRATEGIES TO PREVENT POST ALLO-SCT RELAPSE
Conference paper
Quek L. et al, (2016), HAEMATOLOGICA, 101, 213 - 213