Recent publications published by researchers at the MRC WIMM.
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.
Lascaux P. et al, (2024), Cell, 187, 5698 - 5718.e26
Isolation and detection of DNA-protein crosslinks in mammalian cells.
Torrecilla I. et al, (2023), Nucleic Acids Res
Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks.
Song W. and Ramadan K., (2023), Mol Cell, 83, 4197 - 4199
ATXN3 controls DNA replication and transcription by regulating chromatin structure.
Hernández-Carralero E. et al, (2023), Nucleic Acids Res, 51, 5396 - 5413
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications.
Kilgas S. and Ramadan K., (2023), Cell Chem Biol, 30, 3 - 21
TEX264 at the intersection of autophagy and DNA repair.
Fielden J. et al, (2022), Autophagy, 18, 40 - 49
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Krastev DB. et al, (2022), Nat Cell Biol, 24, 62 - 73
Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells.
Kilgas S. et al, (2021), STAR Protoc, 2
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.
Ruggiano A. et al, (2021), Cell Rep, 37
Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review.
Bolland H. et al, (2021), Biochem Soc Trans, 49, 1251 - 1263
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Kilgas S. et al, (2021), Cell Rep, 35
Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.
Herbert KJ. et al, (2021), Cell Death Differ, 28, 1333 - 1346
SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Na J. et al, (2021), Cell Death Dis, 12
DNA-protein crosslink proteases in genome stability.
Ruggiano A. and Ramadan K., (2021), Commun Biol, 4
The Trinity of SPRTN Protease Regulation.
Ruggiano A. and Ramadan K., (2021), Trends Biochem Sci, 46, 2 - 4
A unified model for the G1/S cell cycle transition.
Hume S. et al, (2020), Nucleic Acids Res, 48, 12483 - 12501
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
Fielden J. et al, (2020), Nat Commun, 11