Recent publications published by researchers at the MRC WIMM.
Isolation and detection of DNA-protein crosslinks in mammalian cells.
Journal article
Torrecilla I. et al, (2023), Nucleic Acids Res
Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks.
Journal article
Song W. and Ramadan K., (2023), Mol Cell, 83, 4197 - 4199
ATXN3 controls DNA replication and transcription by regulating chromatin structure.
Journal article
Hernández-Carralero E. et al, (2023), Nucleic Acids Res, 51, 5396 - 5413
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications.
Journal article
Kilgas S. and Ramadan K., (2023), Cell Chem Biol, 30, 3 - 21
TEX264 at the intersection of autophagy and DNA repair.
Journal article
Fielden J. et al, (2022), Autophagy, 18, 40 - 49
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.
Journal article
Krastev DB. et al, (2022), Nat Cell Biol, 24, 62 - 73
Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells.
Journal article
Kilgas S. et al, (2021), STAR Protoc, 2
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.
Journal article
Ruggiano A. et al, (2021), Cell Rep, 37
The NUCKS1-SKP2-p21/p27 axis controls S phase entry.
Journal article
Hume S. et al, (2021), Nat Commun, 12
Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review.
Journal article
Bolland H. et al, (2021), Biochem Soc Trans, 49, 1251 - 1263
p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation.
Journal article
Kilgas S. et al, (2021), Cell Rep, 35
Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.
Journal article
Herbert KJ. et al, (2021), Cell Death Differ, 28, 1333 - 1346
SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Journal article
Na J. et al, (2021), Cell Death Dis, 12
DNA-protein crosslink proteases in genome stability.
Journal article
Ruggiano A. and Ramadan K., (2021), Commun Biol, 4
The Trinity of SPRTN Protease Regulation.
Journal article
Ruggiano A. and Ramadan K., (2021), Trends Biochem Sci, 46, 2 - 4
A unified model for the G1/S cell cycle transition.
Journal article
Hume S. et al, (2020), Nucleic Acids Res, 48, 12483 - 12501
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts.
Journal article
Fielden J. et al, (2020), Nat Commun, 11
SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
Journal article
Vaz B. et al, (2020)
The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.
Journal article
Singh AN. et al, (2019), EMBO J, 38
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
Journal article
Halder S. et al, (2019), Nat Commun, 10