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Recent publications published by researchers at the MRC WIMM.

Embracing cancer complexity: Hallmarks of systemic disease.

Journal article

Swanton C. et al, (2024), Cell, 187, 1589 - 1616

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.

Journal article

Wang M. et al, (2023), Mol Cell, 83, 2417 - 2433.e7

Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links.

Journal article

Morton SB. et al, (2023), J Am Chem Soc, 145, 953 - 959

Genotoxic aldehydes in the hematopoietic system.

Journal article

Wang M. et al, (2022), Blood, 139, 2119 - 2129

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.

Journal article

Mulderrig L. et al, (2021), Nature, 600, 158 - 163

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Journal article

Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9

Amino acid dependent formaldehyde metabolism in mammals.

Journal article

Pietzke M. et al, (2020), Commun Chem, 3

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

Journal article

Hodskinson MR. et al, (2020), Nature, 579, 603 - 608

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Journal article

Alcón P. et al, (2020), Nat Struct Mol Biol, 27, 240 - 248

Structure of the Fanconi anaemia monoubiquitin ligase complex.

Journal article

Shakeel S. et al, (2019), Nature, 575, 234 - 237

TRAIP is a master regulator of DNA interstrand crosslink repair.

Journal article

Wu RA. et al, (2019), Nature, 567, 267 - 272

Increased formate overflow is a hallmark of oxidative cancer.

Journal article

Meiser J. et al, (2018), Nat Commun, 9

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Journal article

Garaycoechea JI. et al, (2018), Nature, 553, 171 - 177

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.

Journal article

Burgos-Barragan G. et al, (2017), Nature, 548, 549 - 554

Of sizzling steaks and DNA repair.

Journal article

Dingler FA. and Patel KJ., (2017), Science, 357, 130 - 131

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