Recent publications published by researchers at the MRC WIMM.
Embracing cancer complexity: Hallmarks of systemic disease.
Swanton C. et al, (2024), Cell, 187, 1589 - 1616
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism.
John T. et al, (2024), Chem Sci, 15, 2509 - 2517
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism.
Pham VN. et al, (2023), Science, 382
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.
Wang M. et al, (2023), Mol Cell, 83, 2417 - 2433.e7
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.
Wit N. et al, (2023), Sci Adv, 9
Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links.
Morton SB. et al, (2023), J Am Chem Soc, 145, 953 - 959
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.
Mulderrig L. et al, (2021), Nature, 600, 158 - 163
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.
Hodskinson MR. et al, (2020), Nature, 579, 603 - 608
FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
Alcón P. et al, (2020), Nat Struct Mol Biol, 27, 240 - 248
Structure of the Fanconi anaemia monoubiquitin ligase complex.
Shakeel S. et al, (2019), Nature, 575, 234 - 237
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Bauer MR. et al, (2019), Future Med Chem, 11, 2491 - 2504
TRAIP is a master regulator of DNA interstrand crosslink repair.
Wu RA. et al, (2019), Nature, 567, 267 - 272
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Baud MGJ. et al, (2018), Eur J Med Chem, 152, 101 - 114
Increased formate overflow is a hallmark of oxidative cancer.
Meiser J. et al, (2018), Nat Commun, 9
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Garaycoechea JI. et al, (2018), Nature, 553, 171 - 177
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G. et al, (2017), Nature, 548, 549 - 554