Recent publications published by researchers at the MRC WIMM.
DNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs.
van der Sluijs RV. et al, (2025), Nucleic Acids Res, 53
Embracing cancer complexity: Hallmarks of systemic disease.
Swanton C. et al, (2024), Cell, 187, 1589 - 1616
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism.
John T. et al, (2024), Chem Sci, 15, 2509 - 2517
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism.
Pham VN. et al, (2023), Science, 382
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.
Wang M. et al, (2023), Mol Cell, 83, 2417 - 2433.e7
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.
Wit N. et al, (2023), Sci Adv, 9
Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links.
Morton SB. et al, (2023), J Am Chem Soc, 145, 953 - 959
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.
Mulderrig L. et al, (2021), Nature, 600, 158 - 163
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.
Hodskinson MR. et al, (2020), Nature, 579, 603 - 608
FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.
Alcón P. et al, (2020), Nat Struct Mol Biol, 27, 240 - 248
Structure of the Fanconi anaemia monoubiquitin ligase complex.
Shakeel S. et al, (2019), Nature, 575, 234 - 237
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
Bauer MR. et al, (2019), Future Med Chem, 11, 2491 - 2504
TRAIP is a master regulator of DNA interstrand crosslink repair.
Wu RA. et al, (2019), Nature, 567, 267 - 272
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Baud MGJ. et al, (2018), Eur J Med Chem, 152, 101 - 114
Increased formate overflow is a hallmark of oxidative cancer.
Meiser J. et al, (2018), Nat Commun, 9
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Garaycoechea JI. et al, (2018), Nature, 553, 171 - 177
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G. et al, (2017), Nature, 548, 549 - 554