Recent publications published by researchers at the MRC WIMM.
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
Murphy L. et al, (2025), Science, 389
CREST-GV: Cell types Ranking and Enrichment Score for selecTive Genetic Variants
Riva S. et al, (2025)
Modelling constant and cell-type specific CTCF sites by using Convolutional Neural Networks
Sanders E. et al, (2025), Proceedings of the International Joint Conference on Neural Networks
TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes
Barrow Molina E. et al, (2025)
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Pagnamenta AT. et al, (2023), Genome Med, 15
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Downes DJ. et al, (2023), Nat Protoc, 18
Ancient genomic linkage couples metabolism with erythroid development.
Preston AE. et al, (2023), bioRxiv
CATCH-UP: A High-Throughput Upstream-Pipeline for Bulk ATAC-Seq and ChIP-Seq Data.
Riva SG. et al, (2023), J Vis Exp
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M. et al, (2023), Nat Commun, 14
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells.
Torres JM. et al, (2023), Wellcome Open Res, 8
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Robbe P. et al, (2022), Nat Genet, 54, 1675 - 1689
LanceOtron: a deep learning peak caller for genome sequencing experiments.
Hentges LD. et al, (2022), Bioinformatics, 38, 4255 - 4263