Recent publications published by researchers at the MRC WIMM.
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes.
Journal article
Xiang G. et al, (2024), bioRxiv
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Journal article
Pagnamenta AT. et al, (2023), Genome Med, 15
Ancient genomic linkage couples metabolism with erythroid development.
Journal article
Preston AE. et al, (2023), bioRxiv
CATCH-UP: A High-Throughput Upstream-Pipeline for Bulk ATAC-Seq and ChIP-Seq Data.
Journal article
Riva SG. et al, (2023), J Vis Exp
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Journal article
Downes DJ. et al, (2023), Nat Protoc
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Journal article
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
Direct correction of haemoglobin E β-thalassaemia using base editors.
Journal article
Badat M. et al, (2023), Nat Commun, 14
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells.
Journal article
Torres JM. et al, (2023), Wellcome Open Res, 8
Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during differentiation
Preprint
Stolper R. et al, (2023)
Chromatin remodeller Chd7 is developmentally regulated in the neural crest by tissue-specific transcription factors
Preprint
Williams R. et al, (2022)
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Journal article
Robbe P. et al, (2022), Nat Genet, 54, 1675 - 1689
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Preprint
Torres JM. et al, (2022)
Natural and Experimental Rewiring of Gene Regulatory Regions.
Journal article
Downes DJ. and Hughes JR., (2022), Annu Rev Genomics Hum Genet, 23, 73 - 97
LanceOtron: a deep learning peak caller for genome sequencing experiments.
Journal article
Hentges LD. et al, (2022), Bioinformatics
The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin.
Journal article
Truch J. et al, (2022), Nat Commun, 13
Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells.
Journal article
Pavlaki I. et al, (2022), PLoS genetics, 18
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
Journal article
Owens DDG. et al, (2022), Nat Commun, 13
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Journal article
Downes DJ. et al, (2022), Nat Protoc, 17, 445 - 475