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Publications

Recent publications published by researchers at the MRC WIMM.

Yolk sac cell atlas reveals multiorgan functions during human early development.

Goh I. et al, (2023), Science, 381

CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies.

Bueno C. et al, (2022), Blood, 140, 38 - 44

Functional impairment of erythropoiesis in Congenital Dyserythropoietic Anaemia type I arises at the progenitor level.

Scott C. et al, (2022), Br J Haematol, 198, e10 - e14

Accelerated epigenetic aging in newborns with Down syndrome

Xu K. et al, (2022), Aging Cell

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome.

Li S. et al, (2022), Blood Adv

Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging.

Watt SM. et al, (2022), Int J Mol Sci, 23

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma.

Trasanidis N. et al, (2022), Blood

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.

Rice S. et al, (2021), Nat Commun, 12

Blood and immune development in human fetal bone marrow and Down syndrome.

Jardine L. et al, (2021), Nature

Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma.

Alvarez-Benayas J. et al, (2021), Nat Commun, 12

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development.

Roy A. et al, (2021), Cell Rep, 36

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia.

Iskander D. et al, (2021), Sci Transl Med, 13

Towards sustained human platelet production for therapeutic use

Watt SM. and Roberts I., (2021), Annals of Blood, 6

Sowing the seeds of leukemia before birth.

Roberts I. and Vyas P., (2021), Science, 373, 155 - 156

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.

Harman JR. et al, (2021), Genome Res, 31, 1159 - 1173

The EHA Research Roadmap: Platelet Disorders.

Balduini C. et al, (2021), Hemasphere, 5

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma.

Ponnusamy K. et al, (2021), Haematologica

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Muskens IS. et al, (2021), Nat Commun, 12

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2021), J Exp Med, 218

Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo.

Adigbli G. et al, (2021), Front Immunol, 12

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