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Publications

Recent publications published by researchers at the MRC WIMM.

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia

Iskander D. et al, (2021), Science Translational Medicine, 13

Sowing the seeds of leukemia before birth.

Roberts I. and Vyas P., (2021), Science, 373, 155 - 156

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.

Harman JR. et al, (2021), Genome Res

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cells

ROY A. et al, (2021), bioRxiv

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma.

Ponnusamy K. et al, (2021), Haematologica

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Muskens IS. et al, (2021), Nat Commun, 12

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2021), J Exp Med, 218

Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo.

Adigbli G. et al, (2021), Front Immunol, 12

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2021), Leukemia, 35, 90 - 106

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood, 136, 2410 - 2415

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

Rice S. et al, (2020), bioRxiv

The genesis of paediatric haematology in the UK.

Roberts I. and Hann I., (2020), Br J Haematol, 191, 593 - 603

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.

Cruz Hernandez D. et al, (2020), Blood, 136, 1460 - 1465

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Thaventhiran JED. et al, (2020), Nature, 584

Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95

Whole-genome sequencing of patients with rare diseases in a national health system.

Turro E. et al, (2020), Nature, 583, 96 - 102

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay.

Juban G. et al, (2020), Haematologica

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Psaila B. et al, (2020), Mol Cell, 78, 477 - 492.e8

A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment.

Farah RA. et al, (2020), J Pediatr Hematol Oncol, 42, e235 - e237

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2020), BioRix

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