Recent publications published by researchers at the MRC WIMM.
Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.
Ren H. et al, (2026), Blood, 147, 180 - 196
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Smith AL. et al, (2025), Blood, 146, 2073 - 2087
Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.
Elliott N. et al, (2025), Blood, 146, 1561 - 1574
Genome-wide association study of somatic GATA1s mutations in newborns with Down syndrome.
Li Y. et al, (2025), Blood Adv, 9, 4235 - 4243
Genome-wide association studies of Down syndrome associated congenital heart defects.
Feldman ER. et al, (2024)
Introduction to a review series on globin disorders.
Coates TD. and Roberts I., (2024), Blood, 144, 797 - 798
Harnessing Single-Cell Technologies in the Search for New Therapies for Diamond-Blackfan Anemia Syndrome.
Iskander D. et al, (2024), Exp Hematol, 135
Backtracking to the future: unraveling the origins of childhood leukemia.
de Smith AJ. et al, (2024), Leukemia, 38, 416 - 419
The Fetal Specific Gene LIN288 Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia
Ling RE. et al, (2024), BLOOD, 144, 199 - 200
Yolk sac cell atlas reveals multiorgan functions during human early development.
Goh I. et al, (2023), Science, 381
Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome.
Li S. et al, (2022), Blood Adv, 6, 4132 - 4136
CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies.
Bueno C. et al, (2022), Blood, 140, 38 - 44
Functional impairment of erythropoiesis in Congenital Dyserythropoietic Anaemia type I arises at the progenitor level.
Scott C. et al, (2022), Br J Haematol, 198, e10 - e14
Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma.
Trasanidis N. et al, (2022), Blood, 139, 1939 - 1953
Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging.
Watt SM. et al, (2022), Int J Mol Sci, 23
The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma.
Ponnusamy K. et al, (2022), Haematologica, 107, 721 - 732
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Rice S. et al, (2021), Nat Commun, 12
Blood and immune development in human fetal bone marrow and Down syndrome.
Jardine L. et al, (2021), Nature, 598, 327 - 331