Recent publications published by researchers at the MRC WIMM.
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Journal article
Muskens IS. et al, (2021), Nat Commun, 12
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
Journal article
Louka E. et al, (2021), J Exp Med, 218
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Journal article
Godfrey L. et al, (2021), Leukemia, 35, 90 - 106
The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.
Journal article
Hua P. et al, (2020), Blood, 136, 2410 - 2415
A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL
Journal article
Rice S. et al, (2020), bioRxiv
The genesis of paediatric haematology in the UK.
Journal article
Roberts I. and Hann I., (2020), Br J Haematol, 191, 593 - 603
Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.
Journal article
Cruz Hernandez D. et al, (2020), Blood, 136, 1460 - 1465
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Other
Thaventhiran JED. et al, (2020), Nature, 584
Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Journal article
Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95
Whole-genome sequencing of patients with rare diseases in a national health system.
Journal article
Turro E. et al, (2020), Nature, 583, 96 - 102
Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay.
Journal article
Juban G. et al, (2020), Haematologica
Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.
Journal article
Psaila B. et al, (2020), Mol Cell, 78, 477 - 492.e8
A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment.
Journal article
Farah RA. et al, (2020), J Pediatr Hematol Oncol, 42, e235 - e237
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
Journal article
Louka E. et al, (2020), BioRix
Whole-genome sequencing of rare disease patients in a national healthcare system
Journal article
ROBERTS I. and WATKINS H., (2020), Nature
Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia.
Journal article
Winer P. et al, (2020), Blood Adv, 4, 672 - 675
Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.
Journal article
Hua P. et al, (2019), Blood, 134, 2111 - 2115
PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup
Conference paper
Trasanidis N. et al, (2019), BLOOD, 134
Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome
Journal article
O'Byrne SI. et al, (2019), Blood, 134, 1206 - 1206
Decoding human fetal liver haematopoiesis.
Journal article
Popescu D-M. et al, (2019), Nature, 574, 365 - 371