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Publications

Recent publications published by researchers at the MRC WIMM.

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Muskens IS. et al, (2021), Nat Commun, 12

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2021), J Exp Med, 218

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2021), Leukemia, 35, 90 - 106

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood, 136, 2410 - 2415

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

Rice S. et al, (2020), bioRxiv

The genesis of paediatric haematology in the UK.

Roberts I. and Hann I., (2020), Br J Haematol, 191, 593 - 603

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.

Cruz Hernandez D. et al, (2020), Blood, 136, 1460 - 1465

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Thaventhiran JED. et al, (2020), Nature, 584

Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95

Whole-genome sequencing of patients with rare diseases in a national health system.

Turro E. et al, (2020), Nature, 583, 96 - 102

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay.

Juban G. et al, (2020), Haematologica

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Psaila B. et al, (2020), Mol Cell, 78, 477 - 492.e8

A Novel Deletion in the RPL5 Gene in a Lebanese Child With Diamond Blackfan Anemia Unresponsive to Steroid Treatment.

Farah RA. et al, (2020), J Pediatr Hematol Oncol, 42, e235 - e237

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2020), BioRix

Whole-genome sequencing of rare disease patients in a national healthcare system

ROBERTS I. and WATKINS H., (2020), Nature

Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia.

Winer P. et al, (2020), Blood Adv, 4, 672 - 675

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.

Hua P. et al, (2019), Blood, 134, 2111 - 2115

PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup

Trasanidis N. et al, (2019), BLOOD, 134

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

O'Byrne SI. et al, (2019), Blood, 134, 1206 - 1206

Decoding human fetal liver haematopoiesis.

Popescu D-M. et al, (2019), Nature, 574, 365 - 371

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