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Publications

Recent publications published by researchers at the MRC WIMM.

Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

Lucas B. et al, (2023), Nature Communications, 14

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk.

White AJ. et al, (2022), J Immunol

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk.

White AJ. et al, (2022), J Immunol

A circulating subset of iNKT cells mediates antitumor and antiviral immunity.

Cui G. et al, (2022), Sci Immunol, 7

Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

Parmigiani E. et al, (2022), Developmental Cell, 57, 1847 - 1865.e9

Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity.

Ruggeri L. et al, (2022), Blood

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment.

Handel AE. et al, (2022), Sci Adv, 8

Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution.

García-León MJ. et al, (2022), Frontiers in immunology, 13

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes.

Apert C. et al, (2022), Frontiers in immunology, 13

P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss.

Stefanski HE. et al, (2022), PLoS One, 17

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.

Rota IA. et al, (2021), Sci Adv, 7

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment

Handel AE. et al, (2021)

RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus.

Jansen K. et al, (2021), Genome Res, 31, 2022 - 2034

Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα).

Bainter W. et al, (2021), Sci Immunol, 6

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2.

Barthlott T. et al, (2021), Nat Commun, 12

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.

Oftedal BE. et al, (2021), Commun Biol, 4

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency

Rota IA. et al, (2021)

Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells

Asnaghi A. et al, (2021), Advanced Functional Materials

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.

Chen J. et al, (2021), Sci Adv, 7

Introduction: thymus development and function in health and disease.

Holländer GA., (2021), Semin Immunopathol, 43, 1 - 3

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