Recent publications published by researchers at the MRC WIMM.
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla
Journal article
Lucas B. et al, (2023), Nature Communications, 14
Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk.
Journal article
White AJ. et al, (2022), J Immunol
Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk.
Journal article
White AJ. et al, (2022), J Immunol
A circulating subset of iNKT cells mediates antitumor and antiviral immunity.
Journal article
Cui G. et al, (2022), Sci Immunol, 7
Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells
Journal article
Parmigiani E. et al, (2022), Developmental Cell, 57, 1847 - 1865.e9
Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity.
Journal article
Ruggeri L. et al, (2022), Blood
Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment.
Journal article
Handel AE. et al, (2022), Sci Adv, 8
Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution.
Journal article
García-León MJ. et al, (2022), Frontiers in immunology, 13
IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes.
Journal article
Apert C. et al, (2022), Frontiers in immunology, 13
P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss.
Journal article
Stefanski HE. et al, (2022), PLoS One, 17
FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.
Journal article
Rota IA. et al, (2021), Sci Adv, 7
Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment
Preprint
Handel AE. et al, (2021)
RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus.
Journal article
Jansen K. et al, (2021), Genome Res, 31, 2022 - 2034
Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα).
Journal article
Bainter W. et al, (2021), Sci Immunol, 6
Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2.
Journal article
Barthlott T. et al, (2021), Nat Commun, 12
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.
Journal article
Oftedal BE. et al, (2021), Commun Biol, 4
A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency
Preprint
Rota IA. et al, (2021)
Thymus Extracellular Matrix-Derived Scaffolds Support Graft-Resident Thymopoiesis and Long-Term In Vitro Culture of Adult Thymic Epithelial Cells
Journal article
Asnaghi A. et al, (2021), Advanced Functional Materials
High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.
Journal article
Chen J. et al, (2021), Sci Adv, 7
Introduction: thymus development and function in health and disease.
Journal article
Holländer GA., (2021), Semin Immunopathol, 43, 1 - 3