Recent publications published by researchers at the MRC WIMM.
Active regulatory elements recruit cohesin to establish cell specific chromatin domains.
Georgiades E. et al, (2025), Sci Rep, 15
Author Correction: The α-globin super-enhancer acts in an orientation-dependent manner.
Kassouf MT. et al, (2025), Nat Commun, 16
The α-globin super-enhancer acts in an orientation-dependent manner.
Kassouf MT. et al, (2025), Nat Commun, 16
Loss-of-Function Variants in SUPT5H as Modifying Factors in Beta-Thalassemia.
Harteveld CL. et al, (2024), Int J Mol Sci, 25
The characteristics of CTCF binding sequences contribute to enhancer blocking activity.
Tsang FH. et al, (2024), Nucleic Acids Res
Developing a pill to treat sickle cell disease.
Higgs D. and Kassouf M., (2024), Science, 385, 27 - 28
Beginnings: The molecular pathology of hemoglobin
Higgs D. and Badat M., (2024), Molecular Hematology, 1 - 16
Haemoglobin Bart's Hydrops Fetalis: Charting the Past and Envisioning the Future.
Amid A. et al, (2024), Blood
Super-enhancers include classical enhancers and facilitators to fully activate gene expression.
Blayney JW. et al, (2023), Cell, 186, 5826 - 5839.e18
RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
Martell DJ. et al, (2023), Dev Cell, 58, 2112 - 2127.e4
Ancient genomic linkage couples metabolism with erythroid development.
Preston AE. et al, (2023), bioRxiv
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M. et al, (2023), Nat Commun, 14
RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
Martell DJ. et al, (2023), medRxiv
Active regulatory elements recruit cohesin to establish cell-specific chromatin domains
Georgiades E. et al, (2023)
The characteristics of CTCF binding sequences contribute to enhancer blocking activity
Tsang F. et al, (2023)