Recent publications published by researchers at the MRC WIMM.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Li H. et al, (2025), Cell, 188, 7175 - 7193.e19
Active regulatory elements recruit cohesin to establish cell specific chromatin domains.
Georgiades E. et al, (2025), Sci Rep, 15
Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis.
Sun T. et al, (2025), Br J Haematol, 206, 1086 - 1091
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis.
Preston AE. et al, (2025), Nat Commun, 16
Author Correction: The α-globin super-enhancer acts in an orientation-dependent manner.
Kassouf MT. et al, (2025), Nat Commun, 16
The α-globin super-enhancer acts in an orientation-dependent manner.
Kassouf MT. et al, (2025), Nat Commun, 16
Erythropoiesis in the human
Higgs DR. et al, (2025), Hoffbrand S Postgraduate Haematology Eighth Edition, 43 - 55
The characteristics of CTCF binding sequences contribute to enhancer blocking activity.
Tsang FH. et al, (2024), Nucleic Acids Res, 52, 10180 - 10193
Hemoglobin Bart's hydrops fetalis: charting the past and envisioning the future.
Amid A. et al, (2024), Blood, 144, 822 - 833
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes.
Xiang G. et al, (2024), Genome Res, 34, 1089 - 1105
Loss-of-Function Variants in SUPT5H as Modifying Factors in Beta-Thalassemia.
Harteveld CL. et al, (2024), Int J Mol Sci, 25
Developing a pill to treat sickle cell disease.
Higgs D. and Kassouf M., (2024), Science, 385, 27 - 28
Beginnings: The molecular pathology of hemoglobin
Higgs D. and Badat M., (2024), Molecular Hematology, 1 - 16
Super-enhancers include classical enhancers and facilitators to fully activate gene expression.
Blayney JW. et al, (2023), Cell, 186, 5826 - 5839.e18
RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
Martell DJ. et al, (2023), Dev Cell, 58, 2112 - 2127.e4
Ancient genomic linkage couples metabolism with erythroid development.
Preston AE. et al, (2023), bioRxiv
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M. et al, (2023), Nat Commun, 14
RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.
Martell DJ. et al, (2023), medRxiv