Recent publications published by researchers at the MRC WIMM.
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism.
John T. et al, (2024), Chem Sci, 15, 2509 - 2517
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9
CDK activity provides temporal and quantitative cues for organizing genome duplication
Perrot A. et al, (2018), PLOS Genetics, 14, e1007214 - e1007214
Bypass of Mutagenic O6-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases
Räz MH. et al, (2016), Chemical Research in Toxicology, 29, 1493 - 1503
Touching base with arginine: recognition of O6-alkyl guanines by alkyltransferase-like protein Atl1
Wilkinson O. et al, (2014), Collection Symposium Series
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations
Zhang F. et al, (2013), Nucleic Acids Research, 41, 5524 - 5532
The nitrosated bile acid DNA lesion O6 -carboxymethylguanine is a substrate for the human DNA repair protein O6 -methylguanine-DNA methyltransferase
Senthong P. et al, (2013), Nucleic Acids Research, 41, 3047 - 3055
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation- interactions
Wilkinson OJ. et al, (2012), Proceedings of the National Academy of Sciences, 109, 18755 - 18760
Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines
Latypov VF. et al, (2012), Molecular Cell, 47, 50 - 60
Flipping of alkylated DNA damage bridges base and nucleotide excision repair
Tubbs JL. et al, (2009), Nature, 459, 808 - 813