Recent publications published by researchers at the MRC WIMM.
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
Murphy L. et al, (2025), Science, 389
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation.
Hosseini A. et al, (2025), Nature
INCA033989: the first shot on goal for MPNs?
Benlabiod C. and Psaila B., (2024), Blood, 144, 2278 - 2279
When, which and how to switch: Navigating JAK inhibitors in myelofibrosis.
O'Sullivan J. et al, (2024), Br J Haematol
A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
Li R. et al, (2024), Sci Transl Med, 16
Bye-bye My-HSC: Antibody Depletion of Myeloid-biased Stem Cells Revitalizes Aged Blood and Boosts Immunity
Shen Y. and Psaila B., (2024), The Hematologist, 21
Generating human bone marrow organoids for disease modeling and drug discovery.
Olijnik A-A. et al, (2024), Nat Protoc, 19, 2117 - 2146
Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib.
Rampotas A. et al, (2024), Blood, 143, 178 - 182
Amplification of Von Willebrand Factor-Positive CALRmut Disease-Initiating Hematopoietic Stem Cells Is Associated to the Activation of the PERK/EiF2a Branch of Unfolded Protein Response
Benlabiod C. et al, (2024), BLOOD, 144, 752 - 753
Development of a First-in-Class CAR-T Therapy Against Calreticulin-Mutant Neoplasms and Evaluation in the Relevant Human Tissue Environment
Rampotas A. et al, (2024), BLOOD, 144, 871 - 872
Diagnosis and evaluation of prognosis of myelofibrosis: A British Society for Haematology Guideline.
McLornan DP. et al, (2024), Br J Haematol, 204, 127 - 135
Implementing human bone marrow organoids to interrogate microenvironmental influences on the efficacy of blood cancer immunotherapies
Wong ZC. et al, (2024), CANCER RESEARCH, 84
Mapping the Human Bone Marrow in Myeloproliferative Neoplasia Using Spatial Transcriptomics
Cooper R. et al, (2024), BLOOD, 144, 876 - 877
Modelling niche influences on blood cancer development
Psaila B., (2024), HEMATOLOGIE, 30, 121 - 122
Real World Efficacy and Safety of Momelotinib for Myelofibrosis: Evaluation of a UK-Wide Study Confirms 40% Anaemia Response Rate in a Non-Clinical Trial Cohort
Rampotas A. et al, (2024), BLOOD, 144, 1804 - 1806