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Publications

Recent publications published by researchers at the MRC WIMM.

Defining the genetic determinants of CD8+T cell receptor repertoire in the context of immune checkpoint blockade

Ng ES. et al, (2024)

Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination.

Watson RA. et al, (2024), J Immunother Cancer, 12

Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes.

Gilchrist JJ. et al, (2024), Cell Genom

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.

Chong AY. et al, (2024), Am J Hum Genet, 111, 295 - 308

Cytomegalovirus infection protects against metastatic melanoma and modulates oncological outcome and toxicity to checkpoint immunotherapy

Milotay G. et al, (2024)

Demultiplexing of single-cell RNA-sequencing data using interindividual variation in gene expression.

Nassiri I. et al, (2024), Bioinform Adv, 4

Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19

Fairfax B. et al, (2024)

Peripheral monocyte transcriptomics associated with immune checkpoint blockade outcomes in metastatic melanoma

Cooper R. et al, (2024)

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation.

Javaid H. et al, (2023), BMC Cancer, 23

scQCEA: a framework for annotation and quality control report of single-cell RNA-sequencing data.

Nassiri I. et al, (2023), BMC Genomics, 24

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

Pairo-Castineira E. et al, (2023), Nature, 619

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.

Pairo-Castineira E. et al, (2023), Nature, 617, 764 - 768

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells.

Mazet JM. et al, (2023), Nat Commun, 14

Characterisation of the genetic determinants of context specific DNA methylation in primary monocytes

Gilchrist J. et al, (2023)

Deep sequencing of the T cell Receptor reveals common and reproducible CD8+signatures of response to checkpoint immunotherapy

Watson R. et al, (2023)

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

Sivakumar S. et al, (2023)

Germline variants associated with toxicity to immune checkpoint blockade.

Groha S. et al, (2022), Nat Med

IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.

Taylor CA. et al, (2022), Nat Med

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.

Kotanidis CP. et al, (2022), Lancet Digit Health, 4, e705 - e716

Genome-wide association study of leprosy in Malawi and Mali.

Gilchrist JJ. et al, (2022), PLoS Pathog, 18

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