Recent publications published by researchers at the MRC WIMM.
Clonal tracing with somatic epimutations reveals dynamics of blood ageing.
Scherer M. et al, (2025), Nature
Protocol for high-quality RNA sequencing, cell surface protein analysis, and genotyping in single cells using TARGET-seq.
Jakobsen NA. et al, (2025), STAR Protoc, 6
Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1.
Agarwal P. et al, (2025), Nature
Risk Stratification in Older Intensively Treated Patients With AML.
Versluis J. et al, (2024), J Clin Oncol, 42, 4084 - 4094
Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved.
Aksöz M. et al, (2024), Sci Immunol, 9
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.
Jakobsen NA. et al, (2024), Cell Stem Cell, 31, 1127 - 1144.e17
A protocol for simultaneous high-sensitivity genotyping and chromatin accessibility profiling in single cells.
Turkalj S. et al, (2023), STAR Protoc, 4
Fractionated vs single-dose gemtuzumab ozogamicin with determinants of benefit in older patients with AML: the UK NCRI AML18 trial.
Freeman SD. et al, (2023), Blood, 142, 1697 - 1707
A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies.
Lachowiez CA. et al, (2023), Blood Cancer Discov, 4, 276 - 293