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Publications

Recent publications published by researchers at the MRC WIMM.

Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease

Ren H. et al, (2025)

The fetal specific geneLIN28Bis essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia

Ling R. et al, (2024)

Backtracking to the future: unraveling the origins of childhood leukemia.

de Smith AJ. et al, (2024), Leukemia, 38, 416 - 419

Aberrant stem cell and developmental programs in pediatric leukemia.

Ling RE. et al, (2024), Front Cell Dev Biol, 12

A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.

Bueno C. et al, (2023), Blood

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.

Crump NT. et al, (2023), Nat Commun, 14

Direct correction of haemoglobin E β-thalassaemia using base editors.

Badat M. et al, (2023), Nat Commun, 14

Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.

Khan AO. et al, (2023), Cancer Discov, 13, 364 - 385

A SINGLE-CELL PROTEIN-TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN

Londono MQ. et al, (2023), EXPERIMENTAL HEMATOLOGY, 124, S129 - S129

DEVELOPMENTAL ORIGINS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

Roy A., (2023), EXPERIMENTAL HEMATOLOGY, 124, S26 - S26

Investigating the roles of fetal-specific genes in hematopoiesis

Welsh A. et al, (2023), JOURNAL OF IMMUNOLOGY, 210

PROM1/CD133 expression identifies highly proliferative MLL-AF4+blasts and correlates with a stem-like gene signature

Cross J. et al, (2023), KLINISCHE PADIATRIE, 235, 193 - 193

CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies.

Bueno C. et al, (2022), Blood, 140, 38 - 44

Processing single-cell RNA-seq datasets using SingCellaR.

Wang G. et al, (2022), STAR Protoc, 3

In utero origin of myelofibrosis presenting in adult monozygotic twins.

Sousos N. et al, (2022), Nat Med, 28, 1207 - 1211

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

Crump NT. et al, (2022)

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome.

Li S. et al, (2022), Blood Adv

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

Khan AO. et al, (2022)

A PROTEIN - TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN

Londono MQ. et al, (2022), EXPERIMENTAL HEMATOLOGY, 111, S127 - S127

CD34+CD19-CD22+B- CELL PROGENITORS MIGHT UNDERLIE PHENOTYPIC ESCAPE IN PATIENTS TREATED WITH CD19-DIRECTED THERAPIES

Menendez P. et al, (2022), EXPERIMENTAL HEMATOLOGY, 111, S112 - S112

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