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Publications

Recent publications published by researchers at the MRC WIMM.

Aberrant stem cell and developmental programs in pediatric leukemia

Journal article

Ling RE. et al, (2024), Frontiers in Cell and Developmental Biology, 12

Backtracking to the future: unraveling the origins of childhood leukemia.

Journal article

de Smith AJ. et al, (2023), Leukemia

A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.

Journal article

Bueno C. et al, (2023), Blood

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.

Journal article

Crump NT. et al, (2023), Nat Commun, 14

Direct correction of haemoglobin E β-thalassaemia using base editors.

Journal article

Badat M. et al, (2023), Nat Commun, 14

Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.

Journal article

Khan AO. et al, (2023), Cancer Discov, 13, 364 - 385

A SINGLE-CELL PROTEIN-TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN

Conference paper

Londono MQ. et al, (2023), EXPERIMENTAL HEMATOLOGY, 124, S129 - S129

DEVELOPMENTAL ORIGINS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

Conference paper

Roy A., (2023), EXPERIMENTAL HEMATOLOGY, 124, S26 - S26

Investigating the roles of fetal-specific genes in hematopoiesis

Conference paper

Welsh A. et al, (2023), JOURNAL OF IMMUNOLOGY, 210

PROM1/CD133 expression identifies highly proliferative MLL-AF4+blasts and correlates with a stem-like gene signature

Conference paper

Cross J. et al, (2023), KLINISCHE PADIATRIE, 235, 193 - 193

Processing single-cell RNA-seq datasets using SingCellaR.

Journal article

Wang G. et al, (2022), STAR Protoc, 3

In utero origin of myelofibrosis presenting in adult monozygotic twins.

Journal article

Sousos N. et al, (2022), Nat Med, 28, 1207 - 1211

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

Preprint

Crump NT. et al, (2022)

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome.

Journal article

Li S. et al, (2022), Blood Adv

CD34+CD19-CD22+ B-cell progenitors might underlie phenotypic escape in patients treated with CD19-directed therapies.

Journal article

Bueno C. et al, (2022), Blood

Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

Preprint

Khan AO. et al, (2022)

A PROTEIN - TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN

Conference paper

Londono MQ. et al, (2022), EXPERIMENTAL HEMATOLOGY, 111, S127 - S127

CD34+CD19-CD22+B- CELL PROGENITORS MIGHT UNDERLIE PHENOTYPIC ESCAPE IN PATIENTS TREATED WITH CD19-DIRECTED THERAPIES

Conference paper

Menendez P. et al, (2022), EXPERIMENTAL HEMATOLOGY, 111, S112 - S112

Human Bone Marrow Organoids Enable the Study of Hematopoietic Cell-Stromal Interactions and Support the Survival of Malignant Cells from Patients

Conference paper

Khan A. et al, (2022), BLOOD, 140, 1679 - 1681

PAF1 AND FACT COOPERATE WITH MLL-AF4 TO DRIVE ENHANCER ACTIVITY IN LEUKEMIA

Conference paper

Milne T. et al, (2022), EXPERIMENTAL HEMATOLOGY, 111, S36 - S36

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