Recent publications published by researchers at the MRC WIMM.
Menin maintains enhancer-promoter interactions in a leukemia-specific manner
Sharlandjieva V. et al, (2026)
Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.
Ren H. et al, (2026), Blood, 147, 180 - 196
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Smith AL. et al, (2025), Blood, 146, 2073 - 2087
PROM1/CD133 marks a proliferative stem cell-like population of blasts in KMT2A rearranged infant ALL.
Cross JW. et al, (2025), Blood Adv, 9, 4607 - 4613
Backtracking the cellular origins of ETV6::RUNX1 childhood acute lymphoblastic leukemia in cord blood (ReCord study)
de Smith A. et al, (2025), BLOOD, 146, 3368 - 3369
TRANSCRIPTION ELONGATION AND ABERRANT ENHANCER ACTIVATION IN LEUKEMIA
Milne T. et al, (2025), EXPERIMENTAL HEMATOLOGY, 151
Backtracking to the future: unraveling the origins of childhood leukemia.
de Smith AJ. et al, (2024), Leukemia, 38, 416 - 419
Aberrant stem cell and developmental programs in pediatric leukemia.
Ling RE. et al, (2024), Front Cell Dev Biol, 12
Blinatumomab with De-Escalated Chemotherapy for Infant KMT2A-Rearranged B-Cell Acute Lymphoblastic Leukemia
Hodder A. et al, (2024), BLOOD, 144, 2816 - 2817
Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity
Smith AL. et al, (2024), BLOOD, 144, 201 - 202
Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan
Isobe T. et al, (2024), BLOOD, 144, 2659 - 2660
The Fetal Specific Gene LIN288 Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia
Ling RE. et al, (2024), BLOOD, 144, 199 - 200
A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.
Bueno C. et al, (2023), Blood, 142, 1752 - 1756
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT. et al, (2023), Nat Commun, 14