Recent publications published by researchers at the MRC WIMM.
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Smith A. et al, (2025), Blood
PROM1/CD133 MARKS A PROLIFERATIVE STEM CELL LIKE POPULATION OF BLASTS IN KMT2A REARRANGED INFANT ALL.
Cross JW. et al, (2025), Blood Adv
Backtracking to the future: unraveling the origins of childhood leukemia.
de Smith AJ. et al, (2024), Leukemia, 38, 416 - 419
Aberrant stem cell and developmental programs in pediatric leukemia.
Ling RE. et al, (2024), Front Cell Dev Biol, 12
Blinatumomab with De-Escalated Chemotherapy for Infant KMT2A-Rearranged B-Cell Acute Lymphoblastic Leukemia
Hodder A. et al, (2024), BLOOD, 144, 2816 - 2817
Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity
Smith AL. et al, (2024), BLOOD, 144, 201 - 202
Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan
Isobe T. et al, (2024), BLOOD, 144, 2659 - 2660
The Fetal Specific Gene LIN288 Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia
Ling RE. et al, (2024), BLOOD, 144, 199 - 200
A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.
Bueno C. et al, (2023), Blood, 142, 1752 - 1756
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT. et al, (2023), Nat Commun, 14
Direct correction of haemoglobin E β-thalassaemia using base editors.
Badat M. et al, (2023), Nat Commun, 14
Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Khan AO. et al, (2023), Cancer Discov, 13, 364 - 385
A SINGLE-CELL PROTEIN-TRANSCRIPTOME ATLAS OF HAEMATOPOIESIS ACROSS THE HUMAN LIFESPAN
Londono MQ. et al, (2023), EXPERIMENTAL HEMATOLOGY, 124, S129 - S129
Bispecific CAR-iNKT Immunotherapy for High Risk MLL- Rearranged Acute Lymphoblastic Leukemia
Ren H. et al, (2023), BLOOD, 142