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Publications

Recent publications published by researchers at the MRC WIMM.

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.

Tsukada K. et al, (2024), Mol Cell

Targeting DNA damage response pathways in cancer.

Groelly FJ. et al, (2023), Nat Rev Cancer, 23, 78 - 94

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

Groelly FJ. et al, (2022), Mol Cell, 82, 3382 - 3397.e7

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.

De Marco Zompit M. et al, (2022), Nat Commun, 13

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.

Hodson C. et al, (2022), Proc Natl Acad Sci U S A, 119

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Shorrocks A-MK. et al, (2021), Nat Commun, 12

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.

Ochi T. et al, (2020), Structure, 28, 674 - 689.e11

How Cells Respond to DNA Breaks in Mitosis.

Blackford AN. and Stucki M., (2020), Trends Biochem Sci, 45, 321 - 331

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.

Mooser C. et al, (2020), Nat Commun, 11

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Leimbacher P-A. et al, (2019), Mol Cell, 74, 571 - 583.e8

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.

Becker JR. et al, (2018), Nat Commun, 9

Structural Insight into BLM Recognition by TopBP1.

Sun L. et al, (2017), Structure, 25, 1582 - 1588.e3

PGBD5 promotes site-specific oncogenic mutations in human tumors.

Henssen AG. et al, (2017), Nat Genet, 49, 1005 - 1014

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.

Blackford AN. and Jackson SP., (2017), Mol Cell, 66, 801 - 817

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G. et al, (2016), Genes Dev, 30, 2152 - 2157

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.

Lescale C. et al, (2016), Cell Rep, 16, 2967 - 2979

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

Harley ME. et al, (2016), Nat Genet, 48, 36 - 43

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

Wijnhoven P. et al, (2015), Mol Cell, 60, 362 - 373

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs MR. et al, (2015), Mol Cell, 59, 462 - 477

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford AN. et al, (2015), Mol Cell, 57, 1133 - 1141

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