Recent publications published by researchers at the MRC WIMM.
Prior knowledge on context-driven DNA fragmentation probabilities can improvede novogenome assembly algorithms
Pflughaupt P. and Sahakyan A., (2025)
Towards the genomic sequence code of DNA fragility for machine learning.
Pflughaupt P. et al, (2024), Nucleic Acids Res
Quantum mechanical electronic and geometric parameters for DNA k-mers as features for machine learning.
Masuda K. et al, (2024), Sci Data, 11
Generalised interrelations among mutation rates drive the genomic compliance of Chargaff's second parity rule.
Pflughaupt P. and Sahakyan AB., (2023), Nucleic Acids Res
ROptimus: a parallel general-purpose adaptive optimisation engine.
Johnson NAG. et al, (2023), Bioinformatics
Generalised interrelations among mutation rates drive the genomic compliance of Chargaff’s second parity rule
Pflughaupt P. and Sahakyan AB., (2022)
Structure-driven effects on genomic DNA damage propensity at G-quadruplex sites
Abdullah AA. et al, (2021)
Thermal and pH stabilities of i-DNA: confronting in vitro experiments with models and in-cell NMR data.
Cheng M. et al, (2021), Angew Chem Int Ed Engl
A Spontaneous Ring-Opening Reaction Leads to a Repair-Resistant Thymine Oxidation Product in Genomic DNA.
Sahakyan AB. et al, (2020), Chembiochem, 21, 320 - 323
Whole genome experimental maps of DNA G-quadruplexes in multiple species.
Marsico G. et al, (2019), Nucleic Acids Res, 47, 3862 - 3874
Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs.
Chan KL. et al, (2018), Chem Commun (Camb), 54, 10878 - 10881
Machine learning model for sequence-driven DNA G-quadruplex formation.
Sahakyan AB. et al, (2017), Sci Rep, 7
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.
Sahakyan AB. et al, (2017), Nat Struct Mol Biol, 24, 243 - 247
Single genome retrieval of context-dependent variability in mutation rates for human germline.
Sahakyan AB. and Balasubramanian S., (2017), BMC Genomics, 18
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.
Kwok CK. et al, (2016), Nat Methods, 13, 841 - 844
Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.
Kwok CK. et al, (2016), Angew Chem Int Ed Engl, 55, 8958 - 8961
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.
Sahakyan AB. and Balasubramanian S., (2016), BMC Genomics, 17