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Publications

Recent publications published by researchers at the MRC WIMM.

Thermal and pH stabilities of i-DNA: confronting in vitro experiments with models and in-cell NMR data.

Cheng M. et al, (2021), Angew Chem Int Ed Engl

A Spontaneous Ring-Opening Reaction Leads to a Repair-Resistant Thymine Oxidation Product in Genomic DNA.

Sahakyan AB. et al, (2020), Chembiochem, 21, 320 - 323

Whole genome experimental maps of DNA G-quadruplexes in multiple species.

Marsico G. et al, (2019), Nucleic Acids Res, 47, 3862 - 3874

Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs.

Chan KL. et al, (2018), Chem Commun (Camb), 54, 10878 - 10881

Machine learning model for sequence-driven DNA G-quadruplex formation.

Sahakyan AB. et al, (2017), Sci Rep, 7

G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.

Sahakyan AB. et al, (2017), Nat Struct Mol Biol, 24, 243 - 247

Single genome retrieval of context-dependent variability in mutation rates for human germline.

Sahakyan AB. and Balasubramanian S., (2017), BMC Genomics, 18

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.

Kwok CK. et al, (2016), Nat Methods, 13, 841 - 844

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.

Kwok CK. et al, (2016), Angew Chem Int Ed Engl, 55, 8958 - 8961

Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.

Sahakyan AB. and Balasubramanian S., (2016), BMC Genomics, 17

Core variability in substitution rates and the basal sequence characteristics of the human genome

Sahakyan A. and Balasubramanian S., (2015)

Selective Chemical Labeling of Natural T Modifications in DNA.

Hardisty RE. et al, (2015), J Am Chem Soc, 137, 9270 - 9272

Revealing the specific solute-solvent interactions via the measurements of the NMR spin-spin coupling constants

Shahkhatuni AA. et al, (2015), Journal of Molecular Structure, 1083, 175 - 178

Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.

Camilloni C. et al, (2014), Proc Natl Acad Sci U S A, 111, 10203 - 10208

ALMOST: an all atom molecular simulation toolkit for protein structure determination.

Fu B. et al, (2014), J Comput Chem, 35, 1101 - 1105

A conformational ensemble derived using NMR methyl chemical shifts reveals a mechanical clamping transition that gates the binding of the HU protein to DNA.

Kannan A. et al, (2014), J Am Chem Soc, 136, 2204 - 2207

A geometrical parametrization of C1'-C5' RNA ribose chemical shifts calculated by density functional theory.

Suardíaz R. et al, (2013), J Chem Phys, 139

Analysis of the contributions of ring current and electric field effects to the chemical shifts of RNA bases.

Sahakyan AB. and Vendruscolo M., (2013), J Phys Chem B, 117, 1989 - 1998

Computational studies of dielectric permittivity effects on chemical shifts of alanine dipeptide

Sahakyan AB., (2012), Chemical Physics Letters, 547, 66 - 72

Correlation of 1J CH spin-spin coupling constants and their solvent sensitivities

Shahkhatuni AA. et al, (2012), Chemical Physics Letters, 542, 56 - 61

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