Recent publications published by researchers at the MRC WIMM.
A Spontaneous Ring-Opening Reaction Leads to a Repair-Resistant Thymine Oxidation Product in Genomic DNA.
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Sahakyan AB. et al, (2020), Chembiochem, 21, 320 - 323
Whole genome experimental maps of DNA G-quadruplexes in multiple species.
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Marsico G. et al, (2019), Nucleic Acids Res, 47, 3862 - 3874
Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs.
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Chan KL. et al, (2018), Chem Commun (Camb), 54, 10878 - 10881
Machine learning model for sequence-driven DNA G-quadruplex formation.
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Sahakyan AB. et al, (2017), Sci Rep, 7
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.
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Sahakyan AB. et al, (2017), Nat Struct Mol Biol, 24, 243 - 247
Single genome retrieval of context-dependent variability in mutation rates for human germline.
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Sahakyan AB. and Balasubramanian S., (2017), BMC Genomics, 18
rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.
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Kwok CK. et al, (2016), Nat Methods, 13, 841 - 844
Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.
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Kwok CK. et al, (2016), Angew Chem Int Ed Engl, 55, 8958 - 8961
Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.
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Sahakyan AB. and Balasubramanian S., (2016), BMC Genomics, 17
Core variability in substitution rates and the basal sequence characteristics of the human genome
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Sahakyan A. and Balasubramanian S., (2015)
Selective Chemical Labeling of Natural T Modifications in DNA.
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Hardisty RE. et al, (2015), J Am Chem Soc, 137, 9270 - 9272
Revealing the specific solute-solvent interactions via the measurements of the NMR spin-spin coupling constants
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Shahkhatuni AA. et al, (2015), Journal of Molecular Structure, 1083, 175 - 178
Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.
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Camilloni C. et al, (2014), Proc Natl Acad Sci U S A, 111, 10203 - 10208
ALMOST: an all atom molecular simulation toolkit for protein structure determination.
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Fu B. et al, (2014), J Comput Chem, 35, 1101 - 1105
A conformational ensemble derived using NMR methyl chemical shifts reveals a mechanical clamping transition that gates the binding of the HU protein to DNA.
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Kannan A. et al, (2014), J Am Chem Soc, 136, 2204 - 2207
A geometrical parametrization of C1'-C5' RNA ribose chemical shifts calculated by density functional theory.
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Suardíaz R. et al, (2013), J Chem Phys, 139
Analysis of the contributions of ring current and electric field effects to the chemical shifts of RNA bases.
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Sahakyan AB. and Vendruscolo M., (2013), J Phys Chem B, 117, 1989 - 1998
Computational studies of dielectric permittivity effects on chemical shifts of alanine dipeptide
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Sahakyan AB., (2012), Chemical Physics Letters, 547, 66 - 72
Correlation of 1J CH spin-spin coupling constants and their solvent sensitivities
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Shahkhatuni AA. et al, (2012), Chemical Physics Letters, 542, 56 - 61
Protein structure validation using side-chain chemical shifts.
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Sahakyan AB. et al, (2012), J Phys Chem B, 116, 4754 - 4759