Recent publications published by researchers at the MRC WIMM.
Elevated hematopoietic stem cell frequency in mouse alveolar bone marrow.
Niizuma K. et al, (2024), Stem Cell Reports
Targeted hematopoietic stem cell depletion through SCF-blockade.
Chan YY. et al, (2024), Stem Cell Res Ther, 15
A developmental route to hematopoietic stem cells.
Wilkinson AC. and de Bruijn MFTR., (2024), Nat Biotechnol
Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors.
Suchy FP. et al, (2024), Nat Biotechnol
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion.
Becker HJ. et al, (2023), Cell Stem Cell, 30, 987 - 1000.e8
In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation.
Bozhilov YK. et al, (2023), Cells, 12
Chemically defined cytokine-free expansion of human haematopoietic stem cells.
Sakurai M. et al, (2023), Nature, 615, 127 - 133
Physioxia improves the selectivity of hematopoietic stem cell expansion cultures
Igarashi KJ. et al, (2023), Blood Advances
Exploiting somatic mutations to decipher human blood production: a natural lineage-tracing strategy
Bloom M. et al, (2023), Experimental Hematology
Ex Vivo Expansion and Genetic Manipulation of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Cultures
Khoo HM. et al, (2022), Journal of Visualized Experiments
Identification and characterization of in vitro expanded hematopoietic stem cells.
Che JLC. et al, (2022), EMBO reports
Streamlined and quantitative detection of chimerism using digital PCR.
Suchy FP. et al, (2022), Scientific reports, 12
A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells
Becker HJ. et al, (2022)
Hematopoietic stem cell gene editing and expansion: State-of-the-art technologies and recent applications
Haltalli MLR. et al, (2022), Experimental Hematology
Immunological barriers to haematopoietic stem cell gene therapy
Charlesworth CT. et al, (2022), Nature Reviews Immunology
Translational research for bone marrow failure patients
Malouf C. et al, (2022), Experimental Hematology, 105, 18 - 21
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo
Sudo K. et al, (2021), Stem Cell Research
Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.
Ochi K. et al, (2021), Nature communications, 12
Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation.
Sommerkamp P. et al, (2021), Exp Hematol, 94, 20 - 25