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Publications

Recent publications published by researchers at the MRC WIMM.

A developmental route to hematopoietic stem cells.

Wilkinson AC. and de Bruijn MFTR., (2024), Nat Biotechnol

Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors.

Suchy FP. et al, (2024), Nat Biotechnol

Take the MYC to expand blood stem cells.

Wilkinson AC., (2024), Blood, 143, 838 - 840

Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion.

Becker HJ. et al, (2023), Cell Stem Cell, 30, 987 - 1000.e8

In Vitro Human Haematopoietic Stem Cell Expansion and Differentiation.

Bozhilov YK. et al, (2023), Cells, 12

Chemically defined cytokine-free expansion of human haematopoietic stem cells.

Sakurai M. et al, (2023), Nature, 615, 127 - 133

Physioxia improves the selectivity of hematopoietic stem cell expansion cultures

Igarashi KJ. et al, (2023), Blood Advances

Exploiting somatic mutations to decipher human blood production: a natural lineage-tracing strategy

Bloom M. et al, (2023), Experimental Hematology

Ex Vivo Expansion and Genetic Manipulation of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Cultures

Khoo HM. et al, (2022), Journal of Visualized Experiments

Identification and characterization of in vitro expanded hematopoietic stem cells.

Che JLC. et al, (2022), EMBO reports

Streamlined and quantitative detection of chimerism using digital PCR.

Suchy FP. et al, (2022), Scientific reports, 12

A Single Cell Cloning Platform for Gene Edited Functional Murine Hematopoietic Stem Cells

Becker HJ. et al, (2022)

Hematopoietic stem cell gene editing and expansion: State-of-the-art technologies and recent applications

Haltalli MLR. et al, (2022), Experimental Hematology

Immunological barriers to haematopoietic stem cell gene therapy

Charlesworth CT. et al, (2022), Nature Reviews Immunology

Translational research for bone marrow failure patients

Malouf C. et al, (2022), Experimental Hematology, 105, 18 - 21

Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo

Sudo K. et al, (2021), Stem Cell Research

Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.

Ochi K. et al, (2021), Nature communications, 12

Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation.

Sommerkamp P. et al, (2021), Exp Hematol, 94, 20 - 25

Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice.

Wilkinson AC. et al, (2021), Nat Commun, 12

Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.

Zaro BW. et al, (2020), eLife, 9

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