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Publications

Recent publications published by researchers at the MRC WIMM.

Backtracking to the future: unraveling the origins of childhood leukemia.

de Smith AJ. et al, (2023), Leukemia

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A.

Brierley CK. et al, (2023), bioRxiv

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner

Luis TC. et al, (2023), Nature Communications, 14

The management of myelofibrosis: A British Society for Haematology Guideline.

McLornan DP. et al, (2023), Br J Haematol

Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis.

Fang Z. et al, (2023), Nat Commun, 14

Outcomes and Characteristics of Non-Melanoma Skin Cancers in Patients with Myeloproliferative Neoplasms on Ruxolitinib.

Rampotas A. et al, (2023), Blood

Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells.

Matsuoka S. et al, (2023), Blood, 142, 1622 - 1632

Diagnosis and evaluation of prognosis of myelofibrosis: A British Society for Haematology Guideline.

McLornan DP. et al, (2023), Br J Haematol

Erythroid differentiation enhances RNA mis-splicing in SF3B1-mutant myelodysplastic syndromes with ring sideroblasts.

Moura PL. et al, (2023), Cancer Res

Patient-reported Outcomes and Quality of Life in Anemic and Symptomatic Patients With Myelofibrosis: Results From the MOMENTUM Study.

Mesa RA. et al, (2023), Hemasphere, 7

RAS-pathway mutations are common in patients with ruxolitinib refractory/intolerant myelofibrosis: molecular analysis of the PAC203 cohort.

O'Sullivan JM. et al, (2023), Leukemia

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner.

Luis TC. et al, (2023), Nat Commun, 14

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.

Rodriguez-Meira A. et al, (2023), Nat Genet, 55, 1531 - 1541

Systemically produced Kit ligand is sufficient to maintain mouse hematopoietic stem cells

NERLOV C. et al, (2023), Blood

Long-term treatment with pacritinib on a compassionate use basis in patients with advanced myelofibrosis.

Harrison C. et al, (2023), Haematologica, 108, 1960 - 1964

Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial.

Harrison CN. et al, (2023), J Clin Oncol

Symptomatic benefit of momelotinib in patients with myelofibrosis: Results from the SIMPLIFY phase III studies.

Mesa RA. et al, (2023), Cancer Med, 12, 10612 - 10624

Quantifying inherent predictability and spatial synchrony in the aphid vector Myzus persicae: field-scale patterns of abundance and regional forecasting error in the UK.

Bell JR. et al, (2023), Pest Manag Sci, 79, 1331 - 1341

MARVEL: an integrated alternative splicing analysis platform for single-cell RNA sequencing data.

Wen WX. et al, (2023), Nucleic Acids Res, 51

MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.

Mascarenhas J. et al, (2023), J Clin Oncol

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