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Publications

Recent publications published by researchers at the MRC WIMM.

Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide

MEAD A. et al, (2020), Leukemia

Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Thaventhiran JED. et al, (2020), Nature, 583, 90 - 95

Whole-genome sequencing of patients with rare diseases in a national health system.

Turro E. et al, (2020), Nature, 583, 96 - 102

Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice.

Lysenko V. et al, (2020), Blood Adv, 4, 2477 - 2488

Rapid Emergence of Chronic Lymphocytic Leukemia During JAK2 Inhibitor Therapy in a Patient With Myelofibrosis.

Sousos N. et al, (2020), Hemasphere, 4

Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study.

Milojkovic D. et al, (2020), Br J Haematol

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.

Psaila B. et al, (2020), Mol Cell, 78, 477 - 492.e8

Real-world data from the United Kingdom on the sequencing of second generation tyrosine kinase inhibitors for the treatment of chronic phase Philadelphia chromosome-positive chronic myeloid leukaemia

Byrne J. et al, (2020), BRITISH JOURNAL OF HAEMATOLOGY, 189, 197 - 198

Red cell transfusion in outpatients with myelodysplastic syndromes: a feasibility and exploratory randomised trial.

Stanworth SJ. et al, (2020), Br J Haematol, 189, 279 - 290

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

Louka E. et al, (2020), BioRix

Predicting ultrahigh risk multiple myeloma by molecular profiling: an analysis of newly diagnosed transplant eligible myeloma XI trial patients.

Shah V. et al, (2020), Leukemia

A physician survey on the application of the British Society for Haematology guidelines for the diagnosis and management of myelofibrosis in the UK.

Harrison CN. et al, (2020), Br J Haematol, 188, e105 - e109

Single-cell sequencing in hematology.

Brierley CK. and Mead AJ., (2020), Curr Opin Oncol, 32, 139 - 145

An ontogenetic switch drives the positive and negative selection of B cells.

Xu X. et al, (2020), Proc Natl Acad Sci U S A, 117, 3718 - 3727

The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission.

Jeanpierre S. et al, (2020), Haematologica

Technological advances and computational approaches for alternative splicing analysis in single cells.

Wen WX. et al, (2020), Comput Struct Biotechnol J, 18, 332 - 343

The poor outcome in high molecular risk, hydroxycarbamide-resistant/intolerant ET is not ameliorated by ruxolitinib.

O'Sullivan JM. et al, (2019), Blood, 134, 2107 - 2111

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.

Di Genua C. et al, (2019), Haematologica, 104, 2215 - 2224

Low-dose methotrexate: potential clinical impact on haematological and constitutional symptoms in myeloproliferative neoplasms.

Francis S. et al, (2019), Br J Haematol, 187, e69 - e72

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.

Gooding S. et al, (2019), Nat Commun, 10

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