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Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG. Castro-Dopico et al. (2019) find a profound induction of anti-commensal IgG in the colonic mucosa of UC patients and outline a pathway whereby FcγR activation by IgG triggers IL-1β production, type 17 immunity, and the exacerbation of inflammation.

Original publication

DOI

10.1016/j.immuni.2019.03.019

Type

Journal article

Journal

Immunity

Publication Date

16/04/2019

Volume

50

Pages

1029 - 1031

Keywords

Colitis, Colitis, Ulcerative, Colon, Genome-Wide Association Study, Humans, Immunoglobulin G, Inflammation, Intestinal Mucosa