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A large proportion of melanoma patients host a spontaneous T-cell response specifically against ML-IAP-derived peptides. In this study, we describe that some ML-IAP-specific cytotoxic T cells isolated from melanoma patients cross react with an epitope from the auto-antigen SS56. SS56 is a recently described target of autoantibody responses in Sjögren's syndrome (SS) as well as systemic lupus erythematosus (SLE). Here, we describe that SS56 is also an auto-antigen for T cells in SS and SLE. Hence, SS56-specific T cells could readily be detected in circulation and among the infiltrating cells of SLE skin lesions. SS56-specific T cells were able to lyse target cells presenting the peptide epitope on the surface. Notably, SS56-specific CD8 T cells isolated from an SS patient cross reacted with the ML-IAP epitope. This early evidence of a target for auto-reactive CTL in SS and SLE patients; it is to our knowledge previously unreported and underscores the important role of CD8 T cells in autoimmune disorders. Furthermore, the cross-reactivity against the auto-antigen SS56 and the tumor-antigen ML-IAP confirms the link between autoimmunity and anti-cancer cellular immune responses.

Original publication

DOI

10.1038/jid.2009.10

Type

Journal article

Journal

J Invest Dermatol

Publication Date

08/2009

Volume

129

Pages

1992 - 1999

Keywords

Adaptor Proteins, Signal Transducing, Autoantigens, Cross Reactions, Epitopes, Flow Cytometry, Humans, Inhibitor of Apoptosis Proteins, Lupus Erythematosus, Systemic, Neoplasm Proteins, Peptide Fragments, Receptors, Antigen, T-Cell, Sjogren's Syndrome, T-Lymphocytes, Cytotoxic, Tripartite Motif Proteins, Ubiquitin-Protein Ligases