Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

DNA ligases are enzymes that catalyze the joining together of two DNA ends, in a manner that requires either adenosine triphosphate (ATP) or NAD+. DNA ligases are hugely important in molecular biology and biotechnology, particularly for their role in gene cloning. They play essential roles in DNA replication and repair processes, and defects in DNA ligase activity in humans can lead to cancer and immunodeficiency.

Original publication

DOI

10.1016/B978-0-12-374984-0.00423-X

Type

Chapter

Book title

Brenner's Encyclopedia of Genetics: Second Edition

Publication Date

27/02/2013

Pages

371 - 372