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A critical role of pattern recognition receptors (PRRs) is to influence adaptive immune responses by regulating antigen presentation. Engagement of PRRs in dendritic cells (DCs) increases MHC class I antigen presentation and CD8+ T-cell activation by cross-presented peptides but the molecular mechanisms underlying these effects are not completely understood. Studies looking at the role of PRRs in cross-presentation have been largely limited to TLRs but the role of other PRRs such as cytosolic nucleotide-binding oligomerization domain-like (NOD-like) receptors remains particularly enigmatic. Here we discuss recent evidence of the role of PRRs on cross-presentation and consider how cytosolic NLR-associated pathways, such as NOD2, may integrate these signals resulting in effective adaptive CD8+ T cells responses.

Original publication

DOI

10.1016/j.molimm.2017.11.028

Type

Journal article

Journal

Mol Immunol

Publication Date

09/2019

Volume

113

Pages

6 - 10

Keywords

CD8+ T cells, Cross-presentation, MHC class I, NLRs, PRRs, Animals, CD8-Positive T-Lymphocytes, Cross-Priming, Humans, Immunity, Innate, NLR Proteins, Receptors, Pattern Recognition, Signal Transduction