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Association of the Db heavy chain with beta 2-microglobulin and expression of Db and Kb at the surface of the cell are induced by specific peptides in the mutant RMA-S. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin, and transport of the antigen-MHC complex to the cell surface.

Original publication




Journal article


Cold Spring Harb Symp Quant Biol

Publication Date



54 Pt 1


299 - 308


Amino Acid Sequence, Animals, Antigen-Presenting Cells, Binding Sites, Cell Line, Cell Membrane, Epitopes, H-2 Antigens, Molecular Sequence Data, Mutation, Viral Proteins, beta 2-Microglobulin