A mutant cell in which association of class I heavy and light chains is induced by viral peptides.
Townsend A., Ohlën C., Foster L., Bastin J., Ljunggren HG., Kärre K.
Association of the Db heavy chain with beta 2-microglobulin and expression of Db and Kb at the surface of the cell are induced by specific peptides in the mutant RMA-S. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin, and transport of the antigen-MHC complex to the cell surface.