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Maturity onset diabetes of the young is inherited as an autosomal dominant condition. Two families with the disease were studied to determine whether the inheritance of this type of diabetes was linked to the insulin gene. A cloned insulin gene probe was hybridised to DNA from the family members and the insulin gene on each chromosome identified by a different fragment length polymorphism. The results showed no linkage between the insulin gene and the inheritance of maturity onset diabetes of the young.

Original publication

DOI

10.1136/bmj.286.6365.590

Type

Journal article

Journal

Br Med J (Clin Res Ed)

Publication Date

19/02/1983

Volume

286

Pages

590 - 592

Keywords

Adolescent, Adult, Age Factors, Chromosome Mapping, DNA, Diabetes Mellitus, Female, Genetic Linkage, Genetic Markers, Humans, Insulin, Male, Pedigree, Polymorphism, Genetic