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Invasive Salmonella disease, in the form of enteric fever and invasive non-typhoidal Salmonella (iNTS) disease, causes substantial morbidity and mortality in children and adults in the developing world. The study of genetic variations in humans and mice that influence susceptibility of the host to Salmonella infection provides important insights into immunity to Salmonella. In this Review, we discuss data that have helped to elucidate the host genetic determinants of human enteric fever and iNTS disease, alongside data from the mouse model of Salmonella infection. Considered together, these studies provide a detailed picture of the immunobiology of human invasive Salmonella disease.

Original publication

DOI

10.1038/nri3858

Type

Journal article

Journal

Nat Rev Immunol

Publication Date

07/2015

Volume

15

Pages

452 - 463

Keywords

Animals, Genetic Predisposition to Disease, Humans, Salmonella Infections