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A probe detecting a hypervariable region (HVR) 3' to the alpha globin locus on chromosome 16 has been used to produce DNA fingerprints. Segregation analysis has revealed multiple, randomly dispersed DNA fragments inherited in a Mendelian fashion with minimal allelism and linkage. The fingerprints are highly polymorphic (probability of chance association between random individuals much less than 10(-14]. The probe is, therefore, a powerful discriminating tool: it is envisaged that this probe will have forensic applications, including paternity cases, and will be informative in linkage analysis.

Original publication

DOI

10.1007/bf00280553

Type

Journal article

Journal

Human genetics

Publication Date

06/1988

Volume

79

Pages

142 - 146

Addresses

Central Research Establishment, Home Office Forensic Science Service, Aldermaston, Reading, Berks, UK.

Keywords

Humans, Globins, DNA, Genetic Markers, Nucleotide Mapping, Chromosome Mapping, Alleles, Female, Male, Genetic Linkage