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Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes.

Original publication




Journal article


Blood Cells Mol Dis

Publication Date





206 - 212


AGM, E, EHT, Endothelial to hematopoietic transition, HSC, HSPC, Hematopoiesis, Hematopoietic stem cell, Hemogenic endothelium, Microenvironment, PAS, aorta-gonad mesonephros, embryonic day, endothelial-to-hematopoietic transition, hematopoietic stem and/or progenitor cells, hematopoietic stem cell, para-aortic splanchnopleura, Animals, Cell Lineage, Cell Transdifferentiation, Cellular Microenvironment, Endothelium, Hematopoiesis, Hematopoietic Stem Cells, Humans, Transcription Factors