A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery.
Dilly SJ., Bell MJ., Clark AJ., Marsh A., Napier RM., Sergeant MJ., Thompson AJ., Taylor PC.
We show that the use of multiple photochemistries is necessary to ensure diverse immobilisation of small molecules for binding of polypeptides using phage display and antibody libraries.