The case of the missing Ks: Base editor screen to assess cellular fitness at single lysines.
Gopala Krishna V., Gautsch VG., D'Angiolella V.
In this issue of Molecular Cell, Bao et al.1 set out to elucidate "functional lysines" in the genome using adenine base editors. The study reveals several cases of alteration of functions that previous canonical CRISPR-Cas9 screens were unable to detect.