Message in a platelet: decoding platelet transcriptomes in myeloproliferative neoplasms.
Shapiro S., Murphy L., Psaila B.
Platelets are anucleate but contain a rich repertoire of mRNAs. In this issue of Cell Reports Medicine, Shen and colleagues1 present platelet transcriptomes from patients with myeloproliferative neoplasms to study disease mechanisms and generate a predictive algorithm for fibrotic progression.