Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.

Original publication




Journal article


Hematol Oncol Clin North Am

Publication Date





279 - 293


Digital pathology, Myeloproliferative neoplasm, Single-cell genomics, Fibrosis, Gene Expression Profiling, Genomics, Humans, Myeloproliferative Disorders, Neoplasms, Neoplastic Stem Cells, Single-Cell Analysis