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Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the two lung Mϕ subsets, so called according to the sites they reside in. These subsets are also defined by their origins and immunological microenvironment, which endow these cells with distinct features and plasticity. This review summarizes the latest definitions and functions of lung Mϕs during homeostasis and provides exemplar of their divergent roles in lung fibrosis.

Original publication




Journal article


J Leukoc Biol

Publication Date





107 - 114


Mϕs, asthma, fibrosis, lung, Animals, Cellular Microenvironment, Disease Susceptibility, Homeostasis, Humans, Immunity, Innate, Lung, Macrophages, Alveolar, Pulmonary Alveoli, Pulmonary Fibrosis