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Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the two lung Mϕ subsets, so called according to the sites they reside in. These subsets are also defined by their origins and immunological microenvironment, which endow these cells with distinct features and plasticity. This review summarizes the latest definitions and functions of lung Mϕs during homeostasis and provides exemplar of their divergent roles in lung fibrosis.

Original publication

DOI

10.1002/JLB.3RU0720-418R

Type

Journal article

Journal

J Leukoc Biol

Publication Date

07/2021

Volume

110

Pages

107 - 114

Keywords

Mϕs, asthma, fibrosis, lung, Animals, Cellular Microenvironment, Disease Susceptibility, Homeostasis, Humans, Immunity, Innate, Lung, Macrophages, Alveolar, Pulmonary Alveoli, Pulmonary Fibrosis