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Tamoxifen treatment in breast cancer patients is associated with increased risk of endometrial malignancies. Significantly, higher AGR2 expression was found in endometrial cancers that developed in women previously treated with tamoxifen compared to those who had not been exposed to tamoxifen. An association of elevated AGR2 level with myometrial invasion occurrence and invasion depth was also found. In vitro analyses identified a stimulatory effect of AGR2 on cellular proliferation. Although adverse tamoxifen effects on endometrial cells remain elusive, our work identifies elevated AGR2 as a candidate tamoxifen-dependent mechanism of action responsible for increased incidence of endometrial cancer.

Original publication

DOI

10.1080/07357907.2017.1309546

Type

Journal article

Journal

Cancer Invest

Publication Date

28/05/2017

Volume

35

Pages

313 - 324

Keywords

AGR2, Breast cancer, Endometrial cancer, Tamoxifen, A549 Cells, Adenocarcinoma, Antineoplastic Agents, Hormonal, Cell Movement, Cell Proliferation, Cell Transformation, Neoplastic, Endometrial Neoplasms, Endometrium, Female, Humans, MCF-7 Cells, Mucoproteins, Neoplasm Invasiveness, Oncogene Proteins, Proteins, RNA Interference, Retrospective Studies, Risk Factors, Signal Transduction, Tamoxifen, Transfection, Up-Regulation