Contact information
Research groups
Yanchun Peng
Senior Research Associate
- DPhil Supervisor
- Human T cell bank team
Reseach Profile
My research focuses on how antigen-specific T cells contribute to the control of viral infections and cancer, using single-cell transcriptomics, multi-omic profiling, and functional immune assays to study immune regulation and cytotoxic T cell mechanisms.
I completed my DPhil in Clinical Medicine at Oxford in 2013, studying HLA-B51–associated HIV-1 viral control. Since then, my work has expanded to include HIV, Hepatitis C, SARS-CoV-2, Mpox, and influenza, as well as tumour-reactive T cells in cancers such as lung cancer and melanoma. Together with colleagues, I have established the Human T Cell Bank at the Institute, comprising antigen-specific T cell clones and lines targeting hundreds of viral and tumour antigens.
Alongside my research, I have served as Assistant Director of Graduate Studies at the Institute for the past four years. I also supervise DPhil students across a range of immunology projects. I am committed to mentoring early-career scientists and advancing translational immunology.
Recent publications
Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cytotoxicity post COVID-19.
Journal article
Liu G. et al, (2025), Nat Commun, 16
Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response.
Journal article
Drennan PG. et al, (2025), Lancet Microbe, 6
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination.
Journal article
Chen J-L. et al, (2025), Nat Commun, 16
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Journal article
Hamid MHBA. et al, (2024), Nat Immunol, 25, 834 - 846
Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy.
Journal article
Chen Q. et al, (2023), Cell Mol Immunol, 20, 1300 - 1312