DPhil, BSc (Hons)
I did my DPhil in the Gene Medicine Research Group and Wolfson College, working under the joint supervision of Prof Stephen Hyde and Prof Deborah Gill. I am currently working as a postdoctoral research associate in the same lab. My research focusses on the development of viral vectors for passive immunisation against Influenza and Ebola.
Conventional vaccines against Influenza often have low efficacy especially in the elderly and immunocompromised patients and require annual reformulation to keep in pace with the antigenic evolution of the flu virus and there is no licensed Ebola vaccine to date. Through collaboration with Prof Alain Townsend, I obtained some potent influenza and Ebola antibodies he isolated from vaccinated donors. I am investigating the feasibility of using viral vectors to deliver genes encoding these antibodies into the lung or muscle and turn these organs into 'antibody factory' to provide protection.
This platform could potentially serve as a more cost-effective, time-responsive and long lasting approach to provide immunisation against infectious diseases.
Broadly inhibiting anti-neuraminidase monoclonal antibodies induced by trivalent influenza vaccine and H7N9 infection in humans.
Rijal P. et al, (2019), J Virol
Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases
De Caneva A. et al, (2018), HUMAN GENE THERAPY, 29, A115 - A115
Lung-targeted lentiviral vector mediates passive immunisation against influenza
Tan TK. et al, (2018), HUMAN GENE THERAPY, 29, A119 - A119
Use of Pseudotyped, Replication-Deficient Influenza to Facilitate Testing of Gene Delivery Strategies for Treatment of Highly Infectious Diseases
Tan TK. et al, (2018), MOLECULAR THERAPY, 26, 242 - 243
Development of Recombinant Adeno-Associated Viral Vector (rAAV) for Passive Immunisation Against Ebola
Tan TK. et al, (2017), MOLECULAR THERAPY, 25, 182 - 182