Colleges
Research groups
Jack Tan
DPhil, BSc (Hons)
Postdoctoral Scientist
I am a EPA Cephalosporin Early Research and Teaching Fellow at St Edmund Hall. I am currently working as a postdoctoral scientist in Alain Townsend lab at the Weatherall Institute of Molecular Medicine on developing a single cycle influenza vaccine (S-FLU) for clinical trials. Apart form that, I am trying to further understand the immune responses against influenza elicited by S-FLU in animal models and humans. We have also recently started developing vaccines and therapeutic antibodies for coronavirus (SARS-nCoV-2).
Recent publications
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly via Spontaneous Amidation.
Journal article
Howarth M. et al, (2020), Angew Chem Int Ed Engl
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Lung-targeting lentiviral vector for passive immunisation against influenza
Journal article
TAN TK. et al, (2020), Thorax
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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Journal article
Zhou D. et al, (2020), Nat Struct Mol Biol
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Journal article
Huo J. et al, (2020), Nat Struct Mol Biol
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Journal article
Huo J. et al, (2020), Cell Host Microbe
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Lung targeting lentiviral vector for passive immunisation against influenza
Working paper
TAN T. et al, (2020)
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Lentiviral-Mediated Expression of Monoclonal Antibodies in the Lung to Protect Against Influenza
Conference paper
Du Y. et al, (2020), MOLECULAR THERAPY, 28, 60 - 60