PhD, MSc, BSc
Research Topic: Deciphering the bone marrow microenvironment in steady state and leukaemia
I joined the Vyas lab in July 2020 as a postdoctoral researcher after completing my PhD and a short postdoc period in the lab of Claudia Waskow in Germany. During my PhD I studied the mechanism of engraftment of human haematopoietic stem cells in novel humanized mouse models and the effects of human cell transplantation on the murine bone marrow environment (bone marrow niche).
My project in the Vyas lab aims at characterising the microenvironment of haematopoietic stem and progenitor cells (HSPCs) as well as leukaemic stem cells (LSCs) in the human bone marrow. For this I am trying to employ methods new to the lab, including 3D imaging and imaging mass cytometry. We want to use a model of human bone organoids, so-called ‘ossicles’, as a surrogate for studying the interaction of human HSPCs and LSCs with cells of their microenvironment and assess the effects perturbations of the niche will have on human HSPC/LSC function and lineage output.
Guezguez B. et al, (2016), Cancer Cell, 29, 61 - 74
Güneş C. et al, (2019), Stem Cell Reports, 12, 1084 - 1098
Rahmig S. et al, (2016), Stem Cell Reports, 7, 591 - 601
Jayavelu AK. et al, (2020), Nature, 588, 157 - 163