Department of Oncology
Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil Biochemistry, University of Oxford 1996
BSc (Hons) Biochemistry, UMIST, 1991
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
Mengoli V. et al, (2022), EMBO J
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Baddock HT. et al, (2022), Nucleic Acids Research
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.
Baddock HT. et al, (2021), Nucleic acids research
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Yosaatmadja Y. et al, (2021), Nucleic Acids Res
Neuronal enhancers are hotspots for DNA single-strand break repair.
Wu W. et al, (2021), Nature