Professor of Molecular Oncology
The study of DNA damage and repair to understand the causes of cancer and improve its treatment.
Director, Oncology Laboratories, WIMM
Head, DNA Damage and Repair Group, Department of Oncology and WIMM
Royal Society Research Fellow, UCL, 2001-2002
Post-Doctoral Fellow, UCL, 1997-2001
D.Phil, University of Oxford 1996
XPF-ERCC1: Linchpin of DNA crosslink repair.
McHugh PJ., (2020), PLoS Genet, 16
Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.
Swift LP. et al, (2020), 2119, 79 - 88
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
Thomas AM. et al, (2019), Chem Commun (Camb), 55, 11671 - 11674
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Doherty W. et al, (2019), Org Biomol Chem, 17, 8094 - 8105
Microhomologies are prevalent at Cas9-induced larger deletions.
Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417