Mariana Pereira Pinho
Postdoctoral Researcher
Tumor-specific T cell response
My research focuses on the analysis of T cells capable of recognizing and reacting to tumor antigens. Specifically, we are interested in evaluating the specificity and function of tumor-reactive CD8 T cells in breast cancer patients.
Key publications
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Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response.
Journal article
Pinho MP. et al, (2019), Oncoimmunology, 8
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Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence
Journal article
Pinho MP. et al, (2022), International Journal of Molecular Sciences, 23, 5396 - 5396
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Dendritic cell membrane CD83 enhances immune responses by boosting intracellular calcium release in T lymphocytes.
Journal article
Pinho MP. et al, (2014), J Leukoc Biol, 95, 755 - 762
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Dendritic-tumor cell hybrids induce tumor-specific immune responses more effectively than the simple mixture of dendritic and tumor cells.
Journal article
Pinho MP. et al, (2016), Cytotherapy, 18, 570 - 580
Recent publications
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Profiling of Tumor-Infiltrating Immune Cells and Their Impact on Survival in Glioblastoma Patients Undergoing Immunotherapy with Dendritic Cells
Journal article
Peres N. et al, (2024), International Journal of Molecular Sciences, 25, 5275 - 5275
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A robust deep learning workflow to predict CD8 + T-cell epitopes.
Journal article
Lee CH. et al, (2023), Genome Med, 15
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Adjuvant Vaccination with Allogenic Dendritic Cells Significantly Prolongs Overall Survival in High-Grade Gliomas: Results of a Phase II Trial
Journal article
Lepski G. et al, (2023), Cancers, 15, 1239 - 1239
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Decitabine increases neoantigen and cancer testis antigen expression to enhance T-cell-mediated toxicity against glioblastoma.
Journal article
Ma R. et al, (2022), Neuro Oncol, 24, 2093 - 2106
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Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence
Journal article
Pinho MP. et al, (2022), International Journal of Molecular Sciences, 23, 5396 - 5396