Contact information
Research groups
James Gilchrist
MRCPCH DPhil
NIHR Academic Clinical Lecturer
I am a paediatric registrar, currently undertaking sub-specialty training in paediatric infectious diseases. I completed my DPhil in Oxford with Adrian Hill’s infectious diseases genetics group (Wellcome Centre for Human Genetics) in 2016, supported by a Wellcome Trust Clinical Research Fellowship. My DPhil studies expanded on a long-standing interest in invasive nontyphoidal Salmonella (iNTS) disease in African children and HIV-infected adults, performing a genome-wide association study of iNTS disease in Kenyan and Malawian children alongside functional validation of disease-associated genetic variation.
I joined the Fairfax group in 2018 supported by an NIHR academic clinical lectureship. My current work aims to understand how environmental exposures, in particular CMV infection, interact with genetic determinants of immune cell function and how this interaction modifies health outcomes. I continue to have an active interest in the host genetic determinants of invasive infection in African children, with ongoing collaborative studies investigating the human genetic determinants of leprosy in African populations and rotavirus disease in Kenyan and Ugandan children (supported by an Academy of Medical Sciences Starter Grant for Clinical Lecturers).
Key publications
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Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults.
Journal article
MacLennan CA. et al, (2010), Science, 328, 508 - 512
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Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.
Journal article
Gilchrist JJ. et al, (2018), Nat Commun, 9
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Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.
Journal article
Wang L. et al, (2017), Sci Adv, 3
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Methylthioadenosine Suppresses Salmonella Virulence.
Journal article
Bourgeois JS. et al, (2018), Infect Immun, 86
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Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency.
Journal article
Gilchrist JJ. et al, (2020), BMC Med, 18
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Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.
Journal article
Kenyan Bacteraemia Study Group None. et al, (2016), Am J Hum Genet, 98, 1092 - 1100
Recent publications
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Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency.
Journal article
Gilchrist JJ. et al, (2020), BMC Med, 18
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Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele.
Journal article
Al-Mossawi H. et al, (2019), Nat Commun, 10
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Shared immunogenetic associations across common pathogens discovered through Multiplex Serology screening in UK Biobank
Conference paper
Chong AY. et al, (2019), EUROPEAN JOURNAL OF HUMAN GENETICS, 27, 1359 - 1360
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The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia.
Journal article
Muriuki JM. et al, (2019), Sci Adv, 5
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Host genetic variants near the PAX5 gene locus associate with susceptibility to invasive group A streptococcal disease
Journal article
Parks T. et al, (2019)