Contact information
Research groups
Websites
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MRC Human Immunology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Graham Ogg
Professor of Dermatology
Skin immunology; T cells; innate lymphoid cells
Skin and mucosae frequently represent the first point of contact with pathogens and allergens, yet we still know relatively little of the role of the surface immune system in clearing such challenges. This is crucially important in understanding the mechanisms of skin diseases and related diseases, and for optimising approaches to cutaneous drug and vaccine delivery. The aim of the group is therefore to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
Recent publications
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Developmental cell programs are co-opted in inflammatory skin disease.
Journal article
Reynolds G. et al, (2021), Science, 371
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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
Journal article
Peng Y. et al, (2020), Nat Immunol, 21, 1336 - 1345
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Innate Lymphocyte Mechanisms in Skin Diseases.
Book
Chen Y-L. et al, (2020), 38, 171 - 202
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Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.
Journal article
Chen Y-L. et al, (2020), J Exp Med, 217
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Natural killer cells get under your skin.
Journal article
Ogg G., (2020), Sci Transl Med, 12