Clinical Research Fellow & DPhil Student
I studied medical sciences at the University of Cambridge, and qualified in clinical medicine from Oxford Medical School in 2014. I am currently working as a Clinical Research Fellow in the MRC Molecular Haematology Unit supervised by Prof Paresh Vyas and Prof Doug Higgs.
My research focuses on how mutations affecting epigenetic regulators lead to clonal expansion in haematopoietic stem and progenitor cells. Proteins that control DNA methylation, such as DNMT3A and TET2, are important in stem cell differentiation and regulating how genes are expressed. Mutations in these genes are commonly found in blood cells of healthy older people, lead to clonal expansion, and are associated with increased risk of developing acute myeloid leukaemia (AML) and other haematological cancers. Through this work, we hope to gain a better understanding of how AML develops and identify new therapeutic targets to improve treatment for patients with leukaemia.
Cellular and molecular basis of haematopoiesis
VYAS P. and JAKOBSEN N., (2019), Oxford Textbook of Medicine
Purine nucleotide metabolism regulates expression of human MICA.
O'Callaghan C. et al, (2018), JOURNAL OF IMMUNOLOGY, 200
From genomics to targeted treatment in haematological malignancies: a focus on acute myeloid leukaemia.
Jakobsen NA. and Vyas P., (2018), Clin Med (Lond), 18, s47 - s53
Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
McCarthy MT. et al, (2018), J Biol Chem, 293, 3913 - 3924
Novel biomarkers for the detection of prostate cancer.
Jakobsen NA. et al, (2016), J Clin Urol, 9, 3 - 10