BMBCh, MRCP, DPhil
Postdoctoral Clinical Research Fellow
I studied medical sciences at the University of Cambridge, and qualified in clinical medicine from Oxford Medical School in 2014. I am currently working as a Clinical Research Fellow in the MRC Molecular Haematology Unit supervised by Prof Paresh Vyas and Prof Doug Higgs.
My research focuses on how mutations affecting epigenetic regulators lead to clonal expansion in haematopoietic stem and progenitor cells. Proteins that control DNA methylation, such as DNMT3A and TET2, are important in stem cell differentiation and regulating how genes are expressed. Mutations in these genes are commonly found in blood cells of healthy older people, lead to clonal expansion, and are associated with increased risk of developing acute myeloid leukaemia (AML) and other haematological cancers. Through this work, we hope to gain a better understanding of how AML develops and identify new therapeutic targets to improve treatment for patients with leukaemia.
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
A phase Ib/II study of ivosidenib with venetoclax +/- azacitidine in IDH1-mutated myeloid malignancies.
Lachowiez CA. et al, (2023), Blood Cancer Discov
Mutation agnostic diagnosis of clonal hematopoiesis of indeterminate potential (CHIP) using fluctuating methylation clocks
Schenck RO. et al, (2022), CANCER RESEARCH, 82
A Randomized Comparison of the Fractionated Versus Single Dose Schedule of Gemtuzumab Ozogamicin at Induction with Determinants of Benefit for Older AML Patients: UK NCRI AML18 Trial Results
Freeman SD. et al, (2022), BLOOD, 140
Dynamics of Clonal Hematopoiesis Inferred By Modelling Deep Bulk Whole-Genome Sequencing Data at a Single Time Point
Ansari-Pour N. et al, (2022), BLOOD, 140, 5753 - 5754