Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Contact information


asger.jakobsen@imm.ox.ac.uk

Asger Jakobsen

BMBCh, MRCP, DPhil

Postdoctoral Clinical Research Fellow

I studied medical sciences at the University of Cambridge, and qualified in clinical medicine from Oxford Medical School in 2014. I am currently working as a Clinical Research Fellow in the MRC Molecular Haematology Unit supervised by Prof Paresh Vyas and Prof Doug Higgs.

My research focuses on how mutations affecting epigenetic regulators lead to clonal expansion in haematopoietic stem and progenitor cells. Proteins that control DNA methylation, such as DNMT3A and TET2, are important in stem cell differentiation and regulating how genes are expressed. Mutations in these genes are commonly found in blood cells of healthy older people, lead to clonal expansion, and are associated with increased risk of developing acute myeloid leukaemia (AML) and other haematological cancers. Through this work, we hope to gain a better understanding of how AML develops and identify new therapeutic targets to improve treatment for patients with leukaemia.