Websites
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MRC Translational Immune Discovery Unit
Research Unit
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MRC Center For Computational Biology
Research Unit
Agne Antanaviciute
BSc MSc PhD
Computational Biologist
I am a junior group leader in computational biology at the MRC Center for Computational Biology and MRC Translational Immune Discovery Unit. My research interests lie at the intersection of computational biology and human immunology, in particular in the applications of ‘omics, single cell and spatial technologies for the better understanding of tissue microenvironment, local tissue dynamics and cellular interactions, how they are established during development, and the molecular perturbations and tissue remodelling that occurs in disease states, in particular in autoimmune and autoinflammatory conditions. In order to address these types of questions, my research focuses on inter-disciplinary expertise in both biology and computational biology to both to extract relevant biological insights from complex datasets and to develop domain-tailored machine learning models and novel computational methods for high-dimensional sequencing data analysis.
Recent publications
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Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease.
Windster JD. et al, (2024), Gastroenterology
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CELLeBT: exploring physical B cell-T cell clonal interactions through single-cell multi-omics
Bashford-Rogers R. et al, (2024)
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Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis.
Gupta T. et al, (2024), Cancer Cell, 42, 797 - 814.e15
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Heterozygous COL17A1 variants are a frequent cause of amelogenesis imperfecta.
Hany U. et al, (2024), J Med Genet, 61, 347 - 355
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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.
Rana N. et al, (2024), Cell, 187, 1011 - 1015