Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Recent medical advances have generated a doubling in life expectancy in the industrialized world. It is well documented that the elderly immune system is unable to fight off infections and fails to respond optimally to vaccinations, contributing to morbidity in old age. The reasons behind the decline of the immune system are not clear. Our hypothesis is that long-lived immune cells have developed a strict regime of waste disposal, called autophagy, that becomes less efficient with age. Autophagy removes obsolete organelles and proteins, preventing, cellular damage or death. We aim to identify cellular pathways that control longevity, which is a central goal in stem cell and cancer biology. We aim to develop novel drugs that rejuvenate stem cells and other long-lived cells such as memory cells via autophagy.

Similar stories

New funding for early diagnosis research using platelets

MRC MHU RDM

Dr Bethan Psaila and her team will investigate the potential of circulating blood platelets for early detection of a range of cancer types.

MRC WIMM's Noemi Roy among seven projects awarded Public Engagement Seed Funding 2020-21

MRC MHU

Dr Noemi Roy has received funding in the 2020-21 round of the Public Engagement with Research Seed Fund as one of seven projects for innovative work to engage the public with medical research.

Research unpicks why immune responses decrease with age

MRC MHU

Study reveals what happens to blood cell production during the ageing process, which could help identify new therapeutic targets.

Study finds new human blood disorder

MRC MHU RDM

The Patel Group have discovered a new human disease caused by formaldehyde accumulation in cells