Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Recent research from the Simon and Jacobsen groups reveals an unexpected role for autophagy in neutrophil development.

Neutrophils are cells of the immune system, essential for fighting bacterial and fungal infections. Within the human bone marrow, one million neutrophils are generated every second, a rapid and complex process requiring substantial energy and key to the body’s immune response to infection. However, the mechanisms that regulate this process are not fully understood, and dysfunctional neutrophil differentiation can lead to disease.

In their latest publication in Immunity, Researchers at the Simon and Jacobsen labs at the MRC WIMM (Radcliffe Department of Medicine) and Kennedy Institute (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) report that autophagy, an intracellular self-eating process, is necessary for successful neutrophil differentiation. Through autophagy, neutrophil precursor cells are able to degrade lipid droplets, which releases fatty acids. This allows a metabolic switch from glycolysis to free fatty acid oxidation, which the researchers have shown to be essential for neutrophil maturation. 

Many myeloid leukemias are characterised by defective differentiation and precursor cell accumulation, and autophagy defects have been reported. The next goal for the researchers is to test whether a metabolic rewiring dependent on autophagy similar to that observed in neutrophils may also take place in acute myebloastic leukemias.

 

Find out more:

Riffelmacher T., et al (2017) Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation, Immunity, 47 466-480

Similar stories

Funding awarded for autoimmune disease research

Dr Kate Attfield awarded project funding by Connect Immune Research and The Lorna and Yuti Chernajovsky Biomedical Research Foundation.

Project funding for personalised childhood cancer treatments

Funding from the Azaylia Foundation will support the Scientific Advances for Infant Leukaemia (SAIL) programme.

MRC National Mouse Genetics Network Research Clusters Announced

Claus Nerlov and Steve Twigg from the MRC WIMM join the new national network for disease modelling.

Defining the role of resident memory B cells in the fight against influenza

Researchers at the Kennedy Institute of Rheumatology and the MRC Human Immunology Unit have used 3D and live-imaging to show how resident memory B cells boost antibodies to fight influenza.

From ‘Ew, gross!’ to ‘Wow!’: Scientists bring immunology to the classroom

For British Science Week, members of the MRC WIMM visited a local Oxfordshire primary school for an interactive science day – one of the first of its kind since the start of the pandemic.